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Association between the NBS1 Glu185Gln polymorphism and breast cancer risk: a meta-analysis.
MedLine Citation:
PMID:  23381647     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Nijmegen breakage syndrome 1 (NBS1), a vital DNA repair protein in the homologous recombination repair pathway and a signal modifier in the intra-S phase checkpoint, plays a critical role in cellular response to DNA damages and the maintenance of genomic stability. The NBS1 Glu185Gln (NBS1 E185Q, NBS1 8360G>C, rs1805794) polymorphism has been indicated to be involved in the development of cancer, but results of previous individual studies on the association between NBS1 Glu185Gln polymorphism and breast cancer risk remain controversial and inconclusive. Our meta-analysis investigated this association for the first time by pooling the odds ratios with corresponding 95 % confidence intervals (95 % CIs) of all individual publications available to date. Overall, 14 separate studies with 6,642 cases and 7,138 controls were finally included into the present meta-analysis after a comprehensive literature search of the PubMed, Embase, Web of Science, and China National Knowledge Infrastructure databases up to October 21, 2012. Overall analysis and subgroup analyses by ethnicity and source of controls were performed. Meta-analysis of total studies showed that the NBS1 Glu185Gln variant carriers were not susceptible to breast cancer (OR(Gln vs. Glu) = 1.05, 95 % CI 0.80-1.39, P (OR) = 0.719; OR (Gln/Gln vs. Glu/Glu) = 0.82, 95 % CI 0.62-1.08, P (OR) = 0.154; OR (Glu/Gln vs. Glu/Glu) = 1.00, 95 % CI 0.90-1.13, P (OR) = 0.939; OR(Gln/Gln + Glu/Gln vs. Glu/Glu) = 0.96, 95 % CI 0.83-1.11, P (OR) = 0.551; OR(Gln/Gln vs. Glu/Glu + Glu/Gln) = 0.84, 95 % CI 0.67-1.05, P (OR) = 0.134). Similar results were observed in heterogeneity-adjusted meta-analysis of all studies. Furthermore, subgroup analyses by ethnicity and source of controls did not identify any appreciable relationship of the NBS1 Glu185Gln polymorphism with breast cancer susceptibility in any populations. Sensitivity analysis by sequentially omitting individual studies confirmed the stability and reliability of our results. Our meta-analysis of currently available data shows no association between the NBS1 Glu185Gln polymorphism and breast cancer risk.
Authors:
Fan Yao; Yue Fang; Bo Chen; Feng Jin; Shubao Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-5
Journal Detail:
Title:  Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine     Volume:  -     ISSN:  1423-0380     ISO Abbreviation:  Tumour Biol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8409922     Medline TA:  Tumour Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Breast Surgery and Surgical Oncology, Research Unit of General Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning Province, 110001, China, doctoryao66@yeah.net.
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