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The Association between Myocardial Iron Load and Ventricular Repolarization Parameters in Asymptomatic Beta-Thalassemia Patients.
MedLine Citation:
PMID:  22666259     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Previous studies have demonstrated impaired ventricular repolarization in patients with β-TM. However, the effect of iron overload with cardiac T2* magnetic resonance imaging (MRI) on cardiac repolarization remains unclear yet. We aimed to examine relationship between repolarization parameters and iron loading using cardiac T2* MRI in asymptomatic β-TM patients. Twenty-two β-TM patients and 22 age- and gender-matched healthy controls were enrolled to the study. From the 12-lead surface electrocardiography, regional and transmyocardial repolarization parameters were evaluated manually by two experienced cardiologists. All patients were also undergone MRI for cardiac T2* evaluation. Cardiac T2* score <20 msec was considered as iron overload status. Of the QT parameters, QT duration, corrected QT interval, and QT peak duration were significantly longer in the β-TM group compared to the healthy controls. T(p) - T(e) and T(p) - T(e) dispersions were also significantly prolonged in β-TM group compared to healthy controls. (T(p) - T(e))/QT was similar between groups. There was no correlation between repolarization parameters and cardiac T2* MRI values. In conclusion, although repolarization parameters were prolonged in asymptomatic β-TM patients compared with control, we could not find any relation between ECG findings and cardiac iron load.
Authors:
Mehmet Kayrak; Kadir Acar; Enes Elvin Gul; Orhan Ozbek; Turyan Abdulhalikov; Osman Sonmez; Hajrudin Alibaşiç
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Publication Detail:
Type:  Journal Article     Date:  2012-05-15
Journal Detail:
Title:  Advances in hematology     Volume:  2012     ISSN:  1687-9112     ISO Abbreviation:  Adv Hematol     Publication Date:  2012  
Date Detail:
Created Date:  2012-06-05     Completed Date:  2012-08-23     Revised Date:  2013-02-26    
Medline Journal Info:
Nlm Unique ID:  101504271     Medline TA:  Adv Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  170510     Citation Subset:  -    
Affiliation:
Department of Cardiology, Meram School of Medicine, Selcuk University, Meram, 42090 Konya, Turkey.
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