Document Detail


The association between a medical history of depression and gestational diabetes in a large multi-ethnic cohort in the United States.
MedLine Citation:
PMID:  23772933     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Both major depression and gestational diabetes mellitus (GDM) are prevalent among women of reproductive age. Our objective was to determine whether a medical history of depression is related to subsequent development of GDM.
METHODS: The Consortium on Safe Labor was a US retrospective cohort study of 228,562 births between 2002 and 2008. Exclusion criteria for the present analysis included multiple gestation pregnancies (n = 5059), pre-existing diabetes (n = 12,771), deliveries <24 weeks (n = 395), site GDM prevalence (<1%) (n = 20, 721) and missing data on pre-pregnancy body mass index (BMI) (n = 61,321). Using generalised estimating equations, we estimated the association between a history of depression and a pregnancy complicated by GDM.
RESULTS: The final analytic population included 121, 260 women contributing 128 295 pregnancies, of which 5606 were affected by GDM. A history of depression was significantly associated with an increased risk of developing GDM (multivariate odds ratio [aOR] = 1.42 [95% confidence interval (CI) 1.26, 1.60]). Adjusting for pre-pregnancy BMI and weight gain during pregnancy attenuated the association, although it remained statistically significant (aOR = 1.17 [95% CI 1.03, 1.33]).
CONCLUSIONS: A history of depression was significantly associated with an increased GDM risk among a large multi-ethnic US cohort of women. If the association is confirmed, depression presents a potentially modifiable risk factor of GDM and provides additional clues to the underlying pathophysiology of GDM.
Authors:
Katherine Bowers; S Katherine Laughon; Sungduk Kim; Sunni L Mumford; Jennifer Brite; Michele Kiely; Cuilin Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2013-05-09
Journal Detail:
Title:  Paediatric and perinatal epidemiology     Volume:  27     ISSN:  1365-3016     ISO Abbreviation:  Paediatr Perinat Epidemiol     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-18     Completed Date:  2014-02-04     Revised Date:  2014-08-10    
Medline Journal Info:
Nlm Unique ID:  8709766     Medline TA:  Paediatr Perinat Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-8     Citation Subset:  IM    
Copyright Information:
Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Continental Population Groups
Depressive Disorder / ethnology*
Diabetes, Gestational / ethnology*
Ethnic Groups
Female
Humans
Odds Ratio
Pregnancy
Retrospective Studies
Risk Factors
Socioeconomic Factors
United States / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
HHSN267200603425C//PHS HHS; Z99 HD999999/HD/NICHD NIH HHS
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