Document Detail

Association between MTHFR polymorphisms and overall survival of colorectal cancer patients in Northeast China.
MedLine Citation:
PMID:  23392576     Owner:  NLM     Status:  In-Data-Review    
A follow-up study has been carried out to assess the association between MTHFR polymorphisms (SNPs) and overall survival (OS) of colorectal cancer (CRC) patients. Data on 411 CRC patients after surgery were tested for the MTHFR 677C > T and 1298A > C polymorphisms. For MTHFR C677T, patients with CT genotype (HR = 1.17; 95 % CI 0.77-1.80) and those with TT genotype (HR = 1.09; 95 % CI 0.67-1.75) had no statistically significant greater risk of dying than those with wild-type genotype. For MTHFR A1298C, the HRs of AC and CC genotype were 1.09 (95 % CI 0.75-1.59) and 0.79 (95 % CI 0.48-1.29) comparing with AA genotype. In the subgroup, 183 patients received chemotherapy treatment, and the HRs of patients with CT and TT genotype were 0.93 (95 % CI 0.50-1.72) and 0.86 (95 % CI 0.44-1.68) for MTHFR C677T. For A1298C polymorphism, AC genotype (HR = 1.39; 95 % CI 0.81-2.39) and CC genotype (HR = 1.22; 95 % CI 0.75-2.00) did not show significant differences. In conclusions, no significant association was observed between the 677C > T and 1298A > C polymorphisms of MTHFR and the prognosis of colorectal cancer patients with curative resection, including all the subjects and the subgroup of chemotherapy.
Lin Zhu; Fan Wang; Fulan Hu; Yibaina Wang; Dandan Li; Xinshu Dong; Binbin Cui; Yashuang Zhao
Related Documents :
3734116 - Serum amyloid a (saa) variations in patients with cancer: correlation with disease acti...
25117746 - Does tumoral (111)in-ibritumomab accumulation correlate with therapeutic effect and out...
7571056 - Prognostic factors of rectum carcinoma--experience of the german multicentre study sgcr...
24917706 - Significance of uracil/tegafur for preventing intravesical recurrence of non-muscle inv...
1469796 - Prognosis of osteosarcoma treated by limb-salvage surgery: the ten-year intergroup stud...
12003186 - Phase ii trial of amonafide in central nervous system tumors: a southwest oncology grou...
Publication Detail:
Type:  Journal Article     Date:  2013-02-08
Journal Detail:
Title:  Medical oncology (Northwood, London, England)     Volume:  30     ISSN:  1559-131X     ISO Abbreviation:  Med. Oncol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435512     Medline TA:  Med Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  467     Citation Subset:  IM    
Department of Epidemiology, Public Health College, Harbin Medical University, 157 Baojian Street, Nangang District, Harbin, Heilongjiang, People's Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hematological abnormalities in severe anorexia nervosa.
Next Document:  miR-130b is an EMT-related microRNA that targets DICER1 for aggression in endometrial cancer.