Document Detail

Association between the interleukin-6 gene -572 C/G polymorphism and the risk of type 2 diabetes mellitus: a meta-analysis of 11,681 subjects.
MedLine Citation:
PMID:  23289913     Owner:  NLM     Status:  MEDLINE    
The association between the interleukin-6 (IL-6) gene -572 C/G (rs1800796) polymorphism and type 2 diabetes mellitus (T2DM) risk remains controversial. Thus, we performed this meta-analysis by searching PubMed, Embase, Web of Science, CBMdisc and CNKI databases until January 30, 2012. In addition, hand searching of the references of identified articles was performed. A total of 10 case-control studies including 11,681 subjects were selected to evaluate the possible association. Our results showed evidence for significant association between the IL-6 gene -572 C/G polymorphism and T2DM risk (for G allele vs. C allele: odds ratio [OR] = 1.29, 95% confidence interval [CI] = 1.09-1.52, P = 0.002, P = 0.008 after Bonferroni testing; for G/G vs. C/C: OR = 1.89, 95% CI = 1.51-2.37, P < 0.00001, P < 0.00004 after Bonferroni testing; for GG vs. G/C + C/C: OR = 1.75, 95% CI = 1.20-2.56, P = 0.004, P = 0.016 after Bonferroni testing; for G/G + G/C vs. C/C: OR = 1.32, 95% CI = 1.11-1.57, P = 0.001, P = 0.004 after Bonferroni testing). In addition, similar results were obtained in the subgroup analysis based on ethnicity. In summary, the present meta-analysis suggests a significant association between the IL-6 gene -572 G allele and increased risk of T2DM.
Yan-Wei Yin; Qian-Qian Sun; Bei-Bei Zhang; Ai-Min Hu; Hong-Li Liu; Qi Wang; Yi-Hua Zeng; Rui-Jia Xu; Zhong-Dong Zhang; Zhi-Guo Zhang
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Publication Detail:
Type:  Journal Article; Meta-Analysis     Date:  2013-01-07
Journal Detail:
Title:  Annals of human genetics     Volume:  77     ISSN:  1469-1809     ISO Abbreviation:  Ann. Hum. Genet.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-19     Completed Date:  2013-05-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0416661     Medline TA:  Ann Hum Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  106-14     Citation Subset:  IM    
Copyright Information:
© 2013 Blackwell Publishing Ltd/University College London.
Department of Emergency, Chinese PLA Air Force General Hospital, 30 Fucheng Road, Haidian District, Beijing, 100142, China.
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MeSH Terms
Case-Control Studies
Diabetes Mellitus, Type 2 / genetics*
Genetic Predisposition to Disease
Interleukin-6 / genetics*
Polymorphism, Genetic*
Risk Factors
Reg. No./Substance:

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