Document Detail

Association between IL-1ra gene polymorphism and premature delivery.
MedLine Citation:
PMID:  14673228     Owner:  NLM     Status:  MEDLINE    
IL-1 receptor antagonist (IL-1ra) gene polymorphism was examined in 95 Israeli preterm newborns and compared to that of adult volunteers. The genotype was determined using PCR amplification of the variable region of intron 2 of the IL-1ra gene. The IL-1raA1 allele was found to be predominant in the two groups. However, a significant higher frequency of IL-1raA2 allele was found in preterm newborns. The difference was mainly due to higher proportion of homozygous for IL-1raA2 in the preterm neonates (19%) as compared with adults (7%). No such association could be demonstrated between IL-1raA2 allele and severe sepsis in preterm newborns. The frequency of IL-1raA2 allele among preterms with a septic episode did not differ significantly from that found in newborns without sepsis. The results suggest an association between the IL-1ra genotype and the incidence of premature delivery.
H Bessler; M Osovsky; L Sirota
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Publication Detail:
Type:  Journal Article     Date:  2003-12-12
Journal Detail:
Title:  Biology of the neonate     Volume:  85     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2004  
Date Detail:
Created Date:  2004-03-30     Completed Date:  2004-10-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  179-83     Citation Subset:  IM    
Copyright Information:
Copyright 2004 S. Karger AG, Basel
Immunology and Hematology Research Laboratory, Rabin Medical Center, Golda Campus, Petah Tiqva, Israel.
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MeSH Terms
DNA / chemistry,  genetics
Electrophoresis, Agar Gel
Genetic Predisposition to Disease
Gestational Age
Infant, Newborn
Infant, Premature / physiology*
Interleukin 1 Receptor Antagonist Protein
Polymerase Chain Reaction
Polymorphism, Genetic / genetics
Sepsis / genetics
Sialoglycoproteins / genetics*
Reg. No./Substance:
0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Sialoglycoproteins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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