| Association between IL-1ra gene polymorphism and premature delivery. | |
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MedLine Citation:
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PMID: 14673228 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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IL-1 receptor antagonist (IL-1ra) gene polymorphism was examined in 95 Israeli preterm newborns and compared to that of adult volunteers. The genotype was determined using PCR amplification of the variable region of intron 2 of the IL-1ra gene. The IL-1raA1 allele was found to be predominant in the two groups. However, a significant higher frequency of IL-1raA2 allele was found in preterm newborns. The difference was mainly due to higher proportion of homozygous for IL-1raA2 in the preterm neonates (19%) as compared with adults (7%). No such association could be demonstrated between IL-1raA2 allele and severe sepsis in preterm newborns. The frequency of IL-1raA2 allele among preterms with a septic episode did not differ significantly from that found in newborns without sepsis. The results suggest an association between the IL-1ra genotype and the incidence of premature delivery. |
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Authors:
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H Bessler; M Osovsky; L Sirota |
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Publication Detail:
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Type: Journal Article Date: 2003-12-12 |
Journal Detail:
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Title: Biology of the neonate Volume: 85 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2004 |
Date Detail:
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Created Date: 2004-03-30 Completed Date: 2004-10-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 179-83 Citation Subset: IM |
Copyright Information:
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Copyright 2004 S. Karger AG, Basel |
Affiliation:
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Immunology and Hematology Research Laboratory, Rabin Medical Center, Golda Campus, Petah Tiqva, Israel. hannab@clalit.org.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alleles DNA / chemistry, genetics Electrophoresis, Agar Gel Female Genetic Predisposition to Disease Gestational Age Humans Infant, Newborn Infant, Premature / physiology* Interleukin 1 Receptor Antagonist Protein Israel Male Polymerase Chain Reaction Polymorphism, Genetic / genetics Sepsis / genetics Sialoglycoproteins / genetics* |
| Chemical | |
Reg. No./Substance:
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0/IL1RN protein, human; 0/Interleukin 1 Receptor Antagonist Protein; 0/Sialoglycoproteins; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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