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Association between Helicobacter pylori Seropositivity and the Coronary Artery Calcium Score in a Screening Population.
MedLine Citation:
PMID:  21927661     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Helicobacter pylori causes numerous extragastric manifestations, including coronary heart disease. The coronary artery calcification (CAC) score, measured using computed tomography (CT) has been used as a screening test for coronary atherosclerosis. This study investigated the association between H. pylori seropositivity and CAC scores in a screening population.
METHODS: Patients who underwent a health checkup between October 2003 and July 2007 and who did not have a history of ischemic heart disease were enrolled in the study. Subjects were screened with a multidetector CT scan to determine the CAC score and for anti-H. pylori antibody immunoglobulin G; traditional risks for coronary heart disease were evaluated using a structured questionnaire, anthropometric measurements, and laboratory tests.
RESULTS: Of the 2,029 subjects enrolled (1,295 males), 1,214 (59.8%) subjects were H. pylori positive and 815 were H. pylori negative. There were no significant differences in the baseline characteristics of the seropositive and seronegative patients. When the CAC presence or absence scores were considered, multivariate analysis revealed that H. pylori seropositivity was statistically associated with the presence of CAC and that this association was stronger in the mild CAC score category.
CONCLUSIONS: H. pylori seropositive patients are at a higher risk for coronary atherosclerosis regardless of traditional cardiovascular risk factors. This association is particularly applicable for early coronary atherosclerosis.
Authors:
Min Jung Park; Seung Ho Choi; Donghee Kim; Seung Joo Kang; Su Jin Chung; Su Yeon Choi; Dae Hyun Yoon; Seon Hee Lim; Young Sun Kim; Jeong Yoon Yim; Joo Sung Kim; Hyun Chae Jung
Publication Detail:
Type:  Journal Article     Date:  2011-08-18
Journal Detail:
Title:  Gut and liver     Volume:  5     ISSN:  2005-1212     ISO Abbreviation:  Gut Liver     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-19     Completed Date:  2011-11-10     Revised Date:  2013-11-13    
Medline Journal Info:
Nlm Unique ID:  101316452     Medline TA:  Gut Liver     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  321-7     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Korea.
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