Document Detail

Association between Helicobacter pylori Infection and Pathological Changes in the Gastric Mucosa in Chinese Children.
MedLine Citation:
PMID:  24429445     Owner:  NLM     Status:  In-Data-Review    
Objective H. pylori infection in children has a high prevalence worldwide. The disease can cause progressive gastric mucosal inflammation, as verified in animal models. However, data from large-scale clinical studies are limited. Methods We examined 1,634 Chinese children with upper gastrointestinal discomfort using endoscopy. The clinical and pathological data of the patients were analyzed. Results A total of 524 (32.1%) patients were infected with H. pylori, and the prevalence of H. pylori infection increased with age. The H. pylori-infected patients exhibited a significantly higher prevalence of active inflammation (26.9% vs. 4.1%), lymphoid follicle formation (18.5% vs. 4.6%) and marked lymphocyte infiltration (19.7% vs. 5.6%). The H. pylori-infected patients also exhibited a significantly higher prevalence of moderate to marked chronic superficial gastritis (41.9% vs. 9.2%) and moderate chronic atrophic gastritis (21.7% vs. 2.6%) than the uninfected patients (p<0.01). Conclusion H. pylori infection is associated with the degree of gastric mucosal inflammation and the severity of different types of chronic gastritis.
Yi Yu; Lin Su; Xinqiong Wang; Xiaojin Wang; Chundi Xu
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Publication Detail:
Type:  Journal Article     Date:  2012-03-01
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  53     ISSN:  1349-7235     ISO Abbreviation:  Intern. Med.     Publication Date:  2014  
Date Detail:
Created Date:  2014-01-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  83-8     Citation Subset:  IM    
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