| Association between HLA inheritance and asthma medication use in HIV positive children. | |
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MedLine Citation:
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PMID: 20613458 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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This study's purpose was to determine whether asthma medication use in HIV positive children is associated with human leukocyte antigen (HLA) alleles. We reviewed HLA and medication data collected during the Women and Infants Transmission Study for 124 HIV positive children and their mothers. Analysis revealed that HLA-A68 (P = 0.006) was independent and predictive for time to first asthma medication use. There was a preventive association of Cw6 (P = 0.008) with asthma time. Highly active antiretroviral therapy (HAART) was also associated with time to first asthma medication use (P = 0.05). HLA alleles may modulate risk of developing a need for asthma medications and seem to function independently of the actions of HAART therapy. |
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Authors:
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Samuel B Foster; Ming Lu; Bruce Thompson; Kenneth C Rich; Larissa M Matukas; Rosemarie Mason; Robert Winchester; Kelly S MacDonald; William T Shearer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: AIDS (London, England) Volume: 24 ISSN: 1473-5571 ISO Abbreviation: AIDS Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-03 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710219 Medline TA: AIDS Country: England |
Other Details:
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Languages: eng Pagination: 2133-5 Citation Subset: IM; X |
Affiliation:
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Baylor College of Medicine and Texas Children's Hospital, Department of Pediatrics, Allergy and Immunology Section, Houston, Texas, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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AI050274-05/AI/NIAID NIH HHS; AI36211/AI/NIAID NIH HHS; HD41983/HD/NICHD NIH HHS; HL079533/HL/NHLBI NIH HHS; ROGB162//Canadian Institutes of Health Research; RR0188/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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