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Association between HIV-1 tropism and CCR5 human haplotype E in a Caucasian population.
MedLine Citation:
PMID:  24508837     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND.: The influence of the diversity of CCR5 on HIV susceptibility and disease progression has been clearly demonstrated but how the variability of this gene influences the HIV tropism is poorly understood. We investigated whether CCR5 haplotypes are associated with HIV tropism in a Caucasian population.
METHODS.: We evaluated 161 HIV-positive subjects in a cross-sectional study. CCR5 haplotypes were derived after genotyping nine CCR2-CCR5 polymorphisms. The HIV subtype was determined by phylogenetic analysis using the Maximum Likelihood method and viral tropism by the genotypic tropism assay (geno2pheno). Associations between CCR5 haplotypes and viral tropism were determined using logistic regression analyses. Samples from 500 blood donors were used to evaluate the representativeness of HIV-positives in terms of CCR5 haplotype distribution.
RESULTS.: The distribution of CCR5 haplotypes was similar in HIV-positive subjects and blood donors. The majority of viruses (93.8%) belonged to HIV-1 CRF06_cpx; 7.5% were X4, and the remaining were R5 tropic. X4 tropic viruses were overrepresented among people with CCR5 human haplotype E (HHE) compared to those without this haplotype (13.0% vs 1.4%; p=0.006). People possessing CCR5 HHE had eleven times increased odds (OR=11.00; 95% CI 1.38 to 87.38) of having X4 tropic viruses than those with non-HHE. After adjusting for antiretroviral therapy (ARV), neither the presence of HHE nor the use of ARV were associated with X4 tropic viruses.
CONCLUSIONS.: Our results suggest that CCR5 HHE as well as ARV treatment might be associated with the presence of HIV-1 X4 tropic viruses.
Authors:
Huik Kristi; Avi Radko; Uibopuu Helen; Pauskar Merit; Margus Tõnu; Karki Tõnis; Krispin Tõnu; Kool Piret; Rüütel Kristi; Talu Ave; Abel-Ollo Katri; Uusküla Anneli; Carrillo Andrew; He Weijing; Ahuja Sunil K; Lutsar Irja
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-2-6
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  -     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2014 Feb 
Date Detail:
Created Date:  2014-2-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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