| Association between Faecalibacterium prausnitzii and dietary fibre in colonic fermentation in healthy human subjects. | |
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MedLine Citation:
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PMID: 20346190 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The intestinal microbiota are a complex ecosystem influencing the immunoregulation of the human host, providing protection from colonising pathogens and producing SCFA as the main energy source of colonocytes. Our objective was to investigate the effect of dietary fibre exclusion and supplementation on the intestinal microbiota and SCFA concentrations. Faecal samples were obtained from healthy volunteers before and after two 14 d periods of consuming formulated diets devoid or supplemented with fibre (14 g/l). The faecal microbiota were analysed using fluorescent in situ hybridisation and SCFA were measured using GLC. There were large and statistically significant reductions in the numbers of the Faecalibacterium prausnitzii (P < or = 0.01) and Roseburia spp. (P < or = 0.01) groups during both the fibre-free and fibre-supplemented diets. Significant and strong positive correlations between the proportion of F. prausnitzii and the proportion of butyrate during both baseline normal diets were found (pre-fibre free r 0.881, P = 0.001; pre-fibre supplemented r 0.844, P = 0.002). A significant correlation was also found between the proportional reduction in F. prausnitzii and the proportional reduction in faecal butyrate during both the fibre-free (r 0.806; P = 0.005) and the fibre-supplemented diet (r 0.749; P = 0.013). These findings may contribute to the understanding of the association between fibre, microbiota and fermentation in health, during enteral nutrition and in disease states such as Crohn's disease. |
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Authors:
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Robin F J Benus; Tjip S van der Werf; Gjalt W Welling; Patricia A Judd; Moira A Taylor; Hermie J M Harmsen; Kevin Whelan |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-03-29 |
Journal Detail:
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Title: The British journal of nutrition Volume: 104 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-25 Completed Date: 2010-09-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
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Languages: eng Pagination: 693-700 Citation Subset: IM |
Affiliation:
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Department of Medical Microbiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands. r.f.j.benus@mmb.umcg.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Butyrates / analysis Colon / metabolism, microbiology* Diet Dietary Fiber / pharmacology* Fatty Acids, Volatile / analysis*, metabolism Feces / chemistry*, microbiology Female Fermentation Fusobacterium / drug effects*, growth & development Humans Male Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Butyrates; 0/Fatty Acids, Volatile |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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