Document Detail


Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patients.
MedLine Citation:
PMID:  20347396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Since inflammation plays a prominent role in the pathogenesis of sickle cell anemia (SCA) and Duffy antigen receptor for chemokines (DARC) modulates the function of inflammatory processes, we analyzed the relationship between the erythrocyte DARC phenotype and clinical expression of SCA. DARC locus was genotyped in 212 SS adult patients followed by the sickle cell center of Guadeloupe (French West Indies). After patients' stratification according to RBC DARC expression, the prevalence of renal disease, leg ulcers, priapism and osteonecrosis was compared between patient groups as well as hematological variables and plasma levels of chemokines. Duffy-positive patients exhibited higher counts of white blood cells (9.95+/-2.36 vs 8.88+/-2.32 10(9)/L, p=0.0066), polynuclear neutrophils (5.1+/-1.73 vs 4.51+/-1.71 10(9)/L, p=0.0227), higher plasma levels of IL-8 (4.46+/-1.22 vs 1.47+/-0.5 pg/mL, p=0.0202) and RANTES (27.8+/-4.3 vs 18.1+/-2.3 ng/mL, p=0.04) than Duffy-negative patients. No association was detected between RBC expression of DARC and the studied complications.
Authors:
Danitza Nebor; Marie Claude Durpes; Danielle Mougenel; Martin Mukisi-Mukaza; Jacques Elion; Marie-Dominique Hardy-Dessources; Marc Romana
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-26
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  136     ISSN:  1521-7035     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-23     Completed Date:  2010-08-06     Revised Date:  2010-08-17    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  116-22     Citation Subset:  IM    
Copyright Information:
(c) 2010 Elsevier Inc. All rights reserved.
Affiliation:
UMR S_763 Inserm / Université des Antilles et de la Guyane, Hôpital RICOU, CHU de Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe.
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MeSH Terms
Descriptor/Qualifier:
Adult
Albuminuria / epidemiology,  etiology,  genetics
Anemia, Sickle Cell / blood*,  complications,  genetics*
Blood Cell Count
Chemokine CCL5 / blood
Creatinine / blood
Duffy Blood-Group System / genetics*
Female
Gene Frequency / genetics
Guadeloupe / epidemiology
Heterozygote
Homozygote
Humans
Inflammation / blood
Interleukin-8 / blood
Leg Ulcer / epidemiology,  etiology,  genetics
Leukocyte Count
Male
Middle Aged
Neutrophils / cytology
Osteonecrosis / epidemiology,  etiology,  genetics
Polymorphism, Single Nucleotide / genetics
Priapism / epidemiology,  etiology,  genetics
Receptors, Cell Surface / genetics*
Tumor Necrosis Factor-alpha / blood
Young Adult
Chemical
Reg. No./Substance:
0/Chemokine CCL5; 0/DARC protein, human; 0/Duffy Blood-Group System; 0/Interleukin-8; 0/Receptors, Cell Surface; 0/Tumor Necrosis Factor-alpha; 60-27-5/Creatinine
Comments/Corrections
Comment In:
Clin Immunol. 2010 Sep;136(3):458-9; author reply 460-1   [PMID:  20638342 ]

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