| Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patients. | |
| | |
MedLine Citation:
|
PMID: 20347396 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Since inflammation plays a prominent role in the pathogenesis of sickle cell anemia (SCA) and Duffy antigen receptor for chemokines (DARC) modulates the function of inflammatory processes, we analyzed the relationship between the erythrocyte DARC phenotype and clinical expression of SCA. DARC locus was genotyped in 212 SS adult patients followed by the sickle cell center of Guadeloupe (French West Indies). After patients' stratification according to RBC DARC expression, the prevalence of renal disease, leg ulcers, priapism and osteonecrosis was compared between patient groups as well as hematological variables and plasma levels of chemokines. Duffy-positive patients exhibited higher counts of white blood cells (9.95+/-2.36 vs 8.88+/-2.32 10(9)/L, p=0.0066), polynuclear neutrophils (5.1+/-1.73 vs 4.51+/-1.71 10(9)/L, p=0.0227), higher plasma levels of IL-8 (4.46+/-1.22 vs 1.47+/-0.5 pg/mL, p=0.0202) and RANTES (27.8+/-4.3 vs 18.1+/-2.3 ng/mL, p=0.04) than Duffy-negative patients. No association was detected between RBC expression of DARC and the studied complications. |
| | |
Authors:
|
Danitza Nebor; Marie Claude Durpes; Danielle Mougenel; Martin Mukisi-Mukaza; Jacques Elion; Marie-Dominique Hardy-Dessources; Marc Romana |
Related Documents
:
|
9841856 - Influence of hemoglobin e trait on the severity of falciparum malaria. 10807826 - Acute chest syndrome in adults with sickle cell disease. 9846016 - A patient with a hemoglobin variant (hb jlome) unexpectedly detected by hplc for glycat... 1765296 - Relationship between peripheral vascular closure and proliferative retinopathy in sickl... 2047516 - Joint and systemic distribution of dialysis amyloid. 8779126 - Topical treatment of life threatening haemoptysis from aspergillomas. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-26 |
Journal Detail:
|
Title: Clinical immunology (Orlando, Fla.) Volume: 136 ISSN: 1521-7035 ISO Abbreviation: Clin. Immunol. Publication Date: 2010 Jul |
Date Detail:
|
Created Date: 2010-06-23 Completed Date: 2010-08-06 Revised Date: 2010-08-17 |
Medline Journal Info:
|
Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: United States |
Other Details:
|
Languages: eng Pagination: 116-22 Citation Subset: IM |
Copyright Information:
|
(c) 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
UMR S_763 Inserm / Université des Antilles et de la Guyane, Hôpital RICOU, CHU de Pointe-à-Pitre, 97159 Pointe-à-Pitre, Guadeloupe. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Albuminuria / epidemiology, etiology, genetics Anemia, Sickle Cell / blood*, complications, genetics* Blood Cell Count Chemokine CCL5 / blood Creatinine / blood Duffy Blood-Group System / genetics* Female Gene Frequency / genetics Guadeloupe / epidemiology Heterozygote Homozygote Humans Inflammation / blood Interleukin-8 / blood Leg Ulcer / epidemiology, etiology, genetics Leukocyte Count Male Middle Aged Neutrophils / cytology Osteonecrosis / epidemiology, etiology, genetics Polymorphism, Single Nucleotide / genetics Priapism / epidemiology, etiology, genetics Receptors, Cell Surface / genetics* Tumor Necrosis Factor-alpha / blood Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Chemokine CCL5; 0/DARC protein, human; 0/Duffy Blood-Group System; 0/Interleukin-8; 0/Receptors, Cell Surface; 0/Tumor Necrosis Factor-alpha; 60-27-5/Creatinine |
| Comments/Corrections | |
Comment In:
|
Clin Immunol. 2010 Sep;136(3):458-9; author reply 460-1
[PMID:
20638342
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Prenatal diagnosis: what do we know of long-term outcomes?
Next Document: Issues in second trimester induced abortion (medical/surgical methods).