| Association between DRD4 gene and performance of children with ADHD in a test of sustained attention. | |
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MedLine Citation:
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PMID: 16781678 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The adoption of neuropsychological tests as endophenotypic measures can provide an increased sensitivity to specific dimensions of attention-deficit/hyperactivity disorder (ADHD). METHODS: The association between a variable number of tandem repeats polymorphism at the dopamine D4 receptor gene (DRD4) and the performance of children and adolescents with ADHD in a continuous performance test (CPT) was evaluated. The sample comprised 90 clinically referred children and adolescents with ADHD. Errors of omission and commission in the CPT were computed and the number of 48-base pairs tandem repeats in the exon III of DRD4 was assessed. RESULTS: The presence of a 7-repeat allele was associated with more errors of commission and the homozygosity of the 4-repeat allele was related to fewer errors of commission and omission even after adjusting for age. CONCLUSIONS: These findings bring further evidence on the role of DRD4 polymorphisms on the performance in sustained attention tasks among children and adolescents with ADHD diagnosis. |
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Authors:
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Christian Kieling; Tatiana Roman; Alysa E Doyle; Mara Helena Hutz; Luis Augusto Rohde |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2006-06-15 |
Journal Detail:
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Title: Biological psychiatry Volume: 60 ISSN: 0006-3223 ISO Abbreviation: Biol. Psychiatry Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-03 Completed Date: 2006-12-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0213264 Medline TA: Biol Psychiatry Country: United States |
Other Details:
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Languages: eng Pagination: 1163-5 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos 2350, Porto Alegre 90035-003, RS, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alleles Attention / physiology* Attention Deficit Disorder with Hyperactivity / genetics*, physiopathology* Child DNA Repeat Expansion / genetics* Exons Female Gene Frequency Humans Linkage Disequilibrium Male Neuropsychological Tests Polymorphism, Genetic Receptors, Dopamine D4 / genetics* |
| Chemical | |
Reg. No./Substance:
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0/DRD4 protein, human; 137750-34-6/Receptors, Dopamine D4 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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