| Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. | |
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MedLine Citation:
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PMID: 20660057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Variation in taste perception of different chemical substances is a well-known phenomenon in both humans and animals. Recent advances in the understanding of sweet taste signaling have identified a number of proteins involved in this signal transduction. We evaluated the hypothesis that sequence variations occurring in genes encoding taste signaling molecules can influence sweet taste perception in humans. Our population consisted of unrelated individuals (n = 160) of Caucasian, African-American, and Asian descent. Threshold and suprathreshold sensitivities of participants for sucrose were estimated using a sorting test and signal detection analysis that produced cumulative R-index area under the curve (AUC) scores. Genetic association analysis revealed significant correlation of sucrose AUC scores with genetic variation occurring in the GNAT3 gene (single point P = 10(-3) to 10(-4)), which encodes the taste-specific G(alpha) protein subunit gustducin. Subsequent sequencing identified additional GNAT3 variations having significant association with sucrose AUC scores. Collectively, GNAT3 polymorphisms explain 13% of the variation in sucrose perception. Our findings underscore the importance of common genetic variants influencing human taste perception. |
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Authors:
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Alexey A Fushan; Christopher T Simons; Jay P Slack; Dennis Drayna |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-07-21 |
Journal Detail:
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Title: Chemical senses Volume: 35 ISSN: 1464-3553 ISO Abbreviation: Chem. Senses Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-20 Completed Date: 2010-12-27 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 8217190 Medline TA: Chem Senses Country: England |
Other Details:
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Languages: eng Pagination: 579-92 Citation Subset: IM |
Affiliation:
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National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Computational Biology Genetic Variation* Humans Perception / physiology* Polymorphism, Genetic* Signal Transduction / genetics* Sucrose / pharmacology* Taste / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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Z01-000046-09//PHS HHS |
| Chemical | |
Reg. No./Substance:
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57-50-1/Sucrose |
| Comments/Corrections | |
Comment In:
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Chem Senses. 2010 Sep;35(7):549-50
[PMID:
20660058
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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