Document Detail

Association between Chronic Blood Pressure Changes and Development of Alzheimer's Disease.
MedLine Citation:
PMID:  22890096     Owner:  NLM     Status:  Publisher    
Epidemiological studies suggest an association between chronic blood pressure (BP) changes and Alzheimer's disease (AD). In particular, there is growing evidence that hypertensive people that do not have their BP adequately treated and controlled in midlife are more likely to develop AD in late-life. It has been hypothesized that cerebrovascular disease is a common pathway which connects hypertension and AD in individuals with apolipoprotein E genotype through brain hypoperfusion and hypoxia. This could accelerate amyloid-β aggregation that disrupts cell-to-cell connectivity and leads to eventual brain neuron loss. Also, high BP contributes to worsen AD by raising oxidative stress and inflammatory response. Aging-related structural and functional disturbances appear to exacerbate the deleterious effect of chronic hypertension on cerebral blood flow autoregulation. There is evidence suggesting that some antihypertensive drug classes reduce the risk and progression of AD more than others. Further prospective randomized studies comparing different classes of antihypertensive drugs are needed to provide more evidence regarding their effects on AD risk. Hypotension could be a consequence of the incident dementia and conversely deteriorate the outcome of AD by worsening brain hypoperfusion. Frequent home BP monitoring should be carried out in AD patients to detect harmful orthostatic hypotension.
Carlos A Feldstein
Related Documents :
6373306 - Captopril reduces purine loss and reperfusion arrhythmias in the rat heart after corona...
17455406 - Treating metabolic impairment and myocardial stunning with phosphodiesterase inhibitor ...
21620606 - Mitochondrial targeted antioxidant peptide ameliorates hypertensive cardiomyopathy.
10825816 - Relationship between aging and recovery of the underlying mucosa immediately after remo...
16700636 - Neuropsychological characteristics of adolescent boys differing in risk for high blood ...
17187766 - Role of bone morphogenetic proteins in cardiac differentiation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-13
Journal Detail:
Title:  Journal of Alzheimer's disease : JAD     Volume:  -     ISSN:  1875-8908     ISO Abbreviation:  J. Alzheimers Dis.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9814863     Medline TA:  J Alzheimers Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Hospital de Clínicas, University of Buenos Aires School of Medicine, Buenos Aires, Argentina.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Synergistic Effect between Apolipoprotein E ?4 and Diabetes Mellitus for Dementia: Result from a Pop...
Next Document:  GRN Variant rs5848 Reduces Plasma and Brain Levels of Granulin in Alzheimer's Disease Patients.