Document Detail

Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study.
MedLine Citation:
PMID:  20719833     Owner:  NLM     Status:  MEDLINE    
CONTEXT: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown.
OBJECTIVE: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status.
DESIGN AND SETTING: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991-1993 and 2002-2004 (mean follow-up, 11.3 yr).
PARTICIPANTS: We studied 2496 men and 1026 women [mean age, 49.4 (sd=6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up.
MAIN OUTCOME MEASURES: We measured change in serum CRP and IL-6 during follow-up.
RESULTS: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07-0.09] mg/liter and 0.04 (95% CI, 0.03-0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05-0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2) was greater: 0.08 (95% CI, 0.06-0.09) mg/liter and 0.11 (95% CI, 0.07-0.14) mg/liter, respectively (P value for interaction=0.002). Similar patterns were observed for changes in BMI and waist circumference.
CONCLUSIONS: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight.
Eleonor I Fransson; G David Batty; Adam G Tabák; Eric J Brunner; Meena Kumari; Martin J Shipley; Archana Singh-Manoux; Mika Kivimäki
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-08-18
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  95     ISSN:  1945-7197     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-06     Completed Date:  2011-01-14     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5370-4     Citation Subset:  AIM; IM    
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MeSH Terms
Biological Markers / blood
Body Composition / physiology*
Body Height
Body Mass Index
Body Weight
C-Reactive Protein / metabolism
Cohort Studies
Follow-Up Studies
Inflammation / blood*,  epidemiology,  metabolism
Interleukin-5 / blood
Middle Aged
Obesity / blood*,  complications,  metabolism
Waist Circumference
Weight Gain / physiology
Grant Support
G0902037//Medical Research Council; R01AG013196/AG/NIA NIH HHS; R01AG034454/AG/NIA NIH HHS; R01HL036310/HL/NHLBI NIH HHS; //British Heart Foundation; //Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/Biological Markers; 0/Interleukin-5; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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