| Association between change in body composition and change in inflammatory markers: an 11-year follow-up in the Whitehall II Study. | |
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MedLine Citation:
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PMID: 20719833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Obesity is associated with low-grade inflammation, but the long-term effects of weight change on inflammation are unknown. OBJECTIVE: The aim was to examine the association of change in weight, body mass index (BMI), and waist circumference with change in C-reactive protein (CRP) and IL-6 and to assess whether this association is modified by baseline obesity status. DESIGN AND SETTING: The design was a prospective cohort study among civil servants (the Whitehall II Study, UK). We used data from two clinical screenings carried out in 1991-1993 and 2002-2004 (mean follow-up, 11.3 yr). PARTICIPANTS: We studied 2496 men and 1026 women [mean age, 49.4 (sd=6.0) yr at baseline] with measurements on inflammatory markers and anthropometry at both baseline and follow-up. MAIN OUTCOME MEASURES: We measured change in serum CRP and IL-6 during follow-up. RESULTS: The mean increases in CRP and IL-6 were 0.08 [95% confidence interval (CI), 0.07-0.09] mg/liter and 0.04 (95% CI, 0.03-0.05) pg/ml per 1-kg increase in body weight during follow-up. Study members with a BMI less than 25 kg/m2 at baseline had an average increase in CRP of 0.06 (95% CI, 0.05-0.08) mg/liter per 1-kg increase in body weight, whereas the increase in those who were overweight (25≤BMI<30 kg/m2) and obese (BMI≥30 kg/m2) was greater: 0.08 (95% CI, 0.06-0.09) mg/liter and 0.11 (95% CI, 0.07-0.14) mg/liter, respectively (P value for interaction=0.002). Similar patterns were observed for changes in BMI and waist circumference. CONCLUSIONS: Those who were overweight or obese at baseline had a greater absolute increase in CRP per unit increase in weight, BMI, and waist circumference than people who were normal weight. |
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Authors:
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Eleonor I Fransson; G David Batty; Adam G Tabák; Eric J Brunner; Meena Kumari; Martin J Shipley; Archana Singh-Manoux; Mika Kivimäki |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-08-18 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: 2011-01-14 Revised Date: 2013-03-28 |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 5370-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London WC1E 6BT, United Kingdom. e.fransson@ucl.ac.uk |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Body Composition / physiology* Body Height Body Mass Index Body Weight C-Reactive Protein / metabolism Cohort Studies Female Follow-Up Studies Humans Inflammation / blood*, epidemiology, metabolism Interleukin-5 / blood Male Middle Aged Obesity / blood*, complications, metabolism Waist Circumference Weight Gain / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01AG013196/AG/NIA NIH HHS; R01AG034454/AG/NIA NIH HHS; R01HL036310/HL/NHLBI NIH HHS; //British Heart Foundation; //Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Interleukin-5; 9007-41-4/C-Reactive Protein |
| Comments/Corrections | |
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