Document Detail


Association between CYP1A2 polymorphisms and clozapine-induced adverse reactions in patients with schizophrenia.
MedLine Citation:
PMID:  22901441     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We investigated the relationships between common polymorphisms in CYP1A2 (CYP1A2(⁎)1C and (⁎)1F), CYP1A2-mRNA levels in circulating lymphocytes and clozapine(CLZ)-induced adverse drug reactions (ADRs) in 34 patients. Patients with ADRs had a higher frequency of CYP1A2 low activity allele combinations (8/12; 67%) and lower CYP1A2-mRNA levels than patients without ADRs (6/22; 27%, P=0.019).
Authors:
Marco Ferrari; Emilio Bolla; Paola Bortolaso; Camilla Callegari; Nicola Poloni; Sergio Lecchini; Simone Vender; Franca Marino; Marco Cosentino
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-16
Journal Detail:
Title:  Psychiatry research     Volume:  -     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Clinical Medicine- Section Clinical and Experimental Pharmacology, University of Insubria, Via Otorino Rossi 9, 21100 Varese, Italy.
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