Document Detail

Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.
MedLine Citation:
PMID:  19075099     Owner:  NLM     Status:  MEDLINE    
Circulating C-reactive protein (CRP) level is associated with cardiovascular disease. Whether this relationship is causal has been subject of debate, especially as a potential therapeutic target. Previous studies have demonstrated an association between circulating CRP levels and arterial pulse wave velocity, an accepted measure of arterial stiffness. We investigated the association between circulating CRP levels, CRP genotype, and aortic pulse wave velocity by examining data on 790 healthy male participants of the Caerphilly study. Circulating CRP levels were associated with aortic pulse wave velocity after adjustment for cardiovascular risk factors and other potential confounders (P=0.001). Three single nucleotide polymorphisms in the CRP gene (rs1130864, rs1800947, and rs1205) were associated with differences in circulating CRP levels (ratio of geometric means: 1.12, 95% CI 1.03 to 1.21, P=0.005; 0.76, 95% CI 0.66 to 0.87, P<0.001; 0.88, 95% CI 0.81 to 0.95, P=0.001, respectively). However, there was no relationship between any of the genotypes and aortic pulse wave velocity (regression coefficient for C:G/G:G versus C:C genotypes for single nucleotide polymorphism rs1800947 beta=0.005; 95% CI, -0.57 to 0.58; P=0.99). These results suggest that although circulating CRP levels are associated with aortic pulse wave velocity, CRP does not have a causal role in the development of arterial stiffness. CRP may simply act as a marker of vascular damage (ie, reverse causality), or the association reflects residual confounding. Further studies are needed to confirm these findings, particularly in view of the central role CRP has played in cardiovascular disease so far.
Wiebke Schumacher; John Cockcroft; Nicholas J Timpson; Carmel M McEniery; John Gallacher; Ann Rumley; Gordon Lowe; George Davey Smith; Ian B Wilkinson; Yoav Ben-Shlomo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-12-15
Journal Detail:
Title:  Hypertension     Volume:  53     ISSN:  1524-4563     ISO Abbreviation:  Hypertension     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-23     Completed Date:  2009-02-13     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  United States    
Other Details:
Languages:  eng     Pagination:  150-7     Citation Subset:  IM    
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MeSH Terms
Aorta / physiology*
Biological Markers / blood
Blood Flow Velocity / genetics,  physiology
C-Reactive Protein / genetics*,  metabolism*
Cardiovascular Diseases / epidemiology,  metabolism,  physiopathology
Cohort Studies
Elasticity / physiology
Middle Aged
Polymorphism, Single Nucleotide / genetics
Prospective Studies
Regional Blood Flow / genetics,  physiology
Risk Factors
Vascular Resistance / genetics,  physiology*
Grant Support
FS/07/001/21990//British Heart Foundation; G0600705//Medical Research Council; RD1634//Medical Research Council; //British Heart Foundation
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein
Comment In:
Hypertension. 2009 Jun;53(6):e39; author reply e40   [PMID:  19414645 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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