Document Detail

Association between asymmetric dimethylarginine and neopterin in patients with and without angiographic coronary artery disease.
MedLine Citation:
PMID:  19522769     Owner:  NLM     Status:  MEDLINE    
The increase of circulating asymmetric dimethylarginine (ADMA) concentrations, a competitive inhibitor of the nitric oxide synthases, is associated with an increased cardiovascular risk and is considered to play a role in endothelial dysfunction. Recently, ADMA production was observed in stimulated human peripheral mononuclear cells. In this study, we examined a potential relationship between concentrations of ADMA and of the immune activation marker neopterin in patients scheduled for coronary angiography. In a cross-sectional approach, blood concentrations of ADMA, homocysteine, neopterin, folic acid and vitamins B6 and B12 were compared in 2030 patients, which were recruited as participants of the LUdwigshafen RIsk and Cardiovascular Health (LURIC) study. ADMA concentrations did not differ between patients with coronary artery disease (CAD) (mean +/- SD: 0.82 +/- 0.15 micromol/l) and controls (0.81 +/- 0.14 micromol/l; Welch's t-test: P = n.s.). ADMA concentrations correlated with homocysteine (r(s) = 0.207) and vitamin B6 (r(s) = -0.190), and an even stronger correlation with neopterin (r(s) = 0.276; all P < 0.0001) was observed. In conclusion, increased ADMA concentrations in patients at risk for atherosclerosis are associated with increased neopterin concentrations. Data suggest that immune activation may contribute to increased ADMA production in CAD patients.
C Murr; A Meinitzer; T Grammer; K Schroecksnadel; B O Böhm; W März; D Fuchs
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  70     ISSN:  1365-3083     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-15     Completed Date:  2009-07-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  IM    
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
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MeSH Terms
Arginine / analogs & derivatives*,  blood
Chromatography, High Pressure Liquid
Coronary Angiography
Coronary Artery Disease / blood*,  immunology*
Cross-Sectional Studies
Folic Acid / blood
Homocysteine / blood
Middle Aged
Neopterin / blood*
Risk Factors
Vitamin B 12 / blood
Vitamin B 6 / blood
Reg. No./Substance:
0/dimethylarginine; 454-28-4/Homocysteine; 59-30-3/Folic Acid; 670-65-5/Neopterin; 68-19-9/Vitamin B 12; 74-79-3/Arginine; 8059-24-3/Vitamin B 6

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