Document Detail

Association between the Asp299Gly polymorphisms in the Toll-like receptor 4 and premature births in the Finnish population.
MedLine Citation:
PMID:  12193670     Owner:  NLM     Status:  MEDLINE    
Premature birth causes significant health risks of the neonate and increases the cost for neonatal care. Urogenital infection, often caused by Gram-negative bacteria, is a known risk factor. Toll-like receptor-4 (TLR4) is the major endotoxin-signaling receptor and as such is crucial for the initiation of the innate immune response against Gram-negative bacteria. Recently, a variant in the human TLR4 gene was shown to be associated with impaired receptor function and an increased likelihood of Gram-negative sepsis. In the present study, we determined whether the same polymorphism in TLR4 gene is associated with an increased risk for premature birth. We analyzed genotypes for a Finnish study population consisting of a total of 351 term infants and 440 premature infants (gestational age <35 wk; 282 singletons, 158 multiples) and 94 mothers for the presence of the TLR4 polymorphisms Asp299Gly and Thr399Ile. These polymorphisms were in linkage disequilibrium. The 299Gly allele frequencies were 10.6% (93 of 880) in premature infants and 8.3% (58 of 72) in term infants. Excluding multiple pregnancies that often result in premature births, 23.8% (67 of 282) of premature infants and 24.2% (15 of 62) of the mothers of premature infants compared with 15.9% (55 of 345) of term infants and 15.0% (3 of 20) of the mothers delivering at term were carriers of the TLR4 variant. The frequencies of 299Gly allele and Asp/Gly or Gly/Gly genotype carrier status in premature singleton infants were higher than in term singleton infants (p = 0.024, p = 0.028, respectively) or in premature multiples (p = 0.036, p = 0.044, respectively). According to the present results an allelic variation in the TLR4 receptor was associated with increased risk of premature birth.
Eva Lorenz; Mikko Hallman; Riitta Marttila; Ritva Haataja; David A Schwartz
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Pediatric research     Volume:  52     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2002 Sep 
Date Detail:
Created Date:  2002-08-23     Completed Date:  2003-04-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  373-6     Citation Subset:  IM    
Department of Internal Medicine, Section of Infectious Diseases, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA.
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MeSH Terms
Aspartic Acid / metabolism*
Drosophila Proteins*
Endotoxins / metabolism
Gene Frequency
Gestational Age
Glycine / metabolism*
Infant, Newborn
Infant, Premature*
Membrane Glycoproteins / genetics*
Obstetric Labor, Premature / genetics*
Polymorphism, Genetic*
Receptors, Cell Surface / genetics*
Risk Factors
Toll-Like Receptor 4
Toll-Like Receptors
Reg. No./Substance:
0/Drosophila Proteins; 0/Endotoxins; 0/Membrane Glycoproteins; 0/Receptors, Cell Surface; 0/TLR4 protein, human; 0/Toll-Like Receptor 4; 0/Toll-Like Receptors; 56-40-6/Glycine; 56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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