Document Detail


Association between ATM 5557G>A polymorphism and breast cancer risk: a meta-analysis.
MedLine Citation:
PMID:  21603857     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Epidemiological studies have evaluated the association between ATM 5557G>A (p.D1853N) polymorphism and breast cancer risk. However, the results remain conflicting rather than conclusive. To derive a more precise estimation of the relationship, we performed this meta-analysis. Systematic searches of PubMed and Medline databases were performed. A total of nine studies included 3155 cases and 2752 controls were identified. When all nine studies were pooled into the meta-analysis, there was no evidence for significant association between 5557G>A mutation and breast cancer risk(for G/A vs. G/G: OR = 1.05, 95% CI = 0.83-1.34; for A/A vs. G/G: OR = 0.77, 95% CI = 0.58-1.03; for dominant model: OR = 1.04, 95% CI = 0.82-1.31; for recessive model: OR = 0.87, 95% CI = 0.69-1.09). In the subgroup analyses by family history and ethnicity, significant associations were found among Amerindians (for G/A vs. G/G: OR = 2.19, 95% CI = 1.38-3.47; for dominant model: OR = 2.15, 95% CI = 1.37-3.38). In summary, the meta-analysis suggest that ATM 5557G>A polymorphism is associated with increased breast cancer risk among Amerindians. However, due to the small subjects included in analysis and the selection bias existed in some studies, the results for Amerindians should be interpreted with caution.
Authors:
Chen Mao; Vincent C H Chung; Ben-Fu He; Rong-Cheng Luo; Jin-Ling Tang
Related Documents :
23650637 - Deconvoluting complex tissues for expression quantitative trait locus-based analyses.
22168467 - Breast cancer worry in further examination of mammography screening - a systematic review.
21687957 - Arsenic trioxide re-sensitizes erα-negative breast cancer cells to endocrine therapy by...
24557437 - The clinicopathologic significance of the loss of baf250a (arid1a) expression in endome...
15235357 - Increased expression of laminin-5 and its prognostic significance in hypopharyngeal can...
19123007 - Polycystic ovary syndrome and fibrocystic breast disease: is there any association?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-21
Journal Detail:
Title:  Molecular biology reports     Volume:  -     ISSN:  1573-4978     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0403234     Medline TA:  Mol Biol Rep     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Epidemiology, School of Public Health and Primary Care, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Antiviral role of toll-like receptors and cytokines against the new 2009 H1N1 virus infection.
Next Document:  Hereditary breast cancer in Middle Eastern and North African (MENA) populations: identification of n...