| Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction. | |
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MedLine Citation:
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PMID: 20975728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The APOA2 gene has been associated with obesity and insulin resistance (IR) in animal and human studies with controversial results. We have reported an APOA2-saturated fat interaction determining body mass index (BMI) and obesity in American populations. This work aims to extend our findings to European and Asian populations. METHODS: Cross-sectional study in 4602 subjects from two independent populations: a high-cardiovascular risk Mediterranean population (n = 907 men and women; aged 67 ± 6 years) and a multiethnic Asian population (n = 2506 Chinese, n = 605 Malays and n = 494 Asian Indians; aged 39 ± 12 years) participating in a Singapore National Health Survey. Anthropometric, clinical, biochemical, lifestyle and dietary variables were determined. Homeostasis model assessment of insulin resistance was used in Asians. We analyzed gene-diet interactions between the APOA2 -265T>C polymorphism and saturated fat intake (<or ≥ 22 g per day) on anthropometric measures and IR. RESULTS: Frequency of CC (homozygous for the minor allele) subjects differed among populations (1-15%). We confirmed a recessive effect of the APOA2 polymorphism and replicated the APOA2-saturated fat interaction on body weight. In Mediterranean individuals, the CC genotype was associated with a 6.8% greater BMI in those consuming a high (P = 0.018), but not a low (P = 0.316) saturated fat diet. Likewise, the CC genotype was significantly associated with higher obesity prevalence in Chinese and Asian Indians only, with a high-saturated fat intake (P = 0.036). We also found a significant APOA2-saturated fat interaction in determining IR in Chinese and Asian Indians (P = 0.026). CONCLUSION: The influence of the APOA2 -265T>C polymorphism on body-weight-related measures was modulated by saturated fat in Mediterranean and Asian populations. |
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Authors:
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D Corella; E S Tai; J V Sorlí; S K Chew; O Coltell; M Sotos-Prieto; A García-Rios; R Estruch; J M Ordovas |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-10-26 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: 35 ISSN: 1476-5497 ISO Abbreviation: Int J Obes (Lond) Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-10 Completed Date: 2011-08-10 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 666-75 Citation Subset: IM |
Affiliation:
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Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111-1524, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Alleles Apolipoprotein A-II / genetics* Asian Continental Ancestry Group / ethnology, genetics* Body Mass Index Body Weight / ethnology, genetics* Cardiovascular Diseases / epidemiology, ethnology, genetics* Cross-Sectional Studies Dietary Fats / adverse effects European Continental Ancestry Group / ethnology, genetics* Female Genetic Predisposition to Disease Genotype Humans Insulin Resistance / ethnology, genetics Male Obesity / epidemiology, ethnology, genetics* Polymorphism, Single Nucleotide |
| Grant Support | |
ID/Acronym/Agency:
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DK075030/DK/NIDDK NIH HHS; HL-54776/HL/NHLBI NIH HHS; R01 DK075030-03/DK/NIDDK NIH HHS; R01 HL054776-13/HL/NHLBI NIH HHS; U 01 HL72524/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/APOA2 protein, human; 0/Apolipoprotein A-II; 0/Dietary Fats |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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