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Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation.
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MedLine Citation:
PMID:  8034748     Owner:  NLM     Status:  MEDLINE    
Basonuclin is a protein possessing three pairs of zinc fingers and a nuclear localization signal. Expression of the gene is largely confined to keratinocytes of stratified squamous epithelia and hair follicles. In the epidermis and in stratified epidermal cultures, basonuclin is present in the nuclei of cells in or close to the basal layer but not in the nuclei of cells in more superficial layers. The Ki-67 protein, a nuclear marker for any stage of the multiplication cycle is present in only a subclass of basonuclin-containing cells. In cultured keratinocytes, the disappearance of basonuclin mRNA is associated with loss of colony-forming ability and the appearance of mRNA for involucrin, a protein characteristic of terminal differentiation. In hair follicles, the largest reservoir of basonuclin-containing cells is the outer root sheath, which contains precursors of differentiated cells of the hair shaft and of the epidermis. Basonuclin is not a cell cycle marker but is likely instead to be a regulatory molecular whose presence in the keratinocyte is linked to the maintenance of proliferative capacity and prevention of terminal differentiation.
H Tseng; H Green
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of cell biology     Volume:  126     ISSN:  0021-9525     ISO Abbreviation:  J. Cell Biol.     Publication Date:  1994 Jul 
Date Detail:
Created Date:  1994-08-12     Completed Date:  1994-08-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0375356     Medline TA:  J Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  495-506     Citation Subset:  IM    
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115.
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MeSH Terms
Cell Differentiation*
Cell Division*
Cell Nucleus / chemistry
Cell Separation
Cells, Cultured
DNA-Binding Proteins
Epidermis / chemistry
Hair / chemistry
Keratinocytes / chemistry*,  cytology,  physiology
Ki-67 Antigen
Neoplasm Proteins / analysis
Nuclear Proteins / analysis
Protein Precursors / analysis,  genetics
Proteins / analysis*,  genetics,  physiology
RNA, Messenger / analysis
S Phase
Skin / chemistry*
Transcription Factors
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Ki-67 Antigen; 0/Neoplasm Proteins; 0/Nuclear Proteins; 0/Phosphoproteins; 0/Protein Precursors; 0/Proteins; 0/RNA, Messenger; 0/Transcription Factors; 148814-46-4/BNC1 protein, human; 60108-77-2/involucrin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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Journal Information
Journal ID (nlm-ta): J Cell Biol
ISSN: 0021-9525
ISSN: 1540-8140
Publisher: The Rockefeller University Press
Article Information
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Print publication date: Day: 2 Month: 7 Year: 1994
Volume: 126 Issue: 2
First Page: 495 Last Page: 506
ID: 2200026
Publisher Id: 94308279
PubMed Id: 8034748

Association of basonuclin with ability of keratinocytes to multiply and with absence of terminal differentiation

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