Document Detail


Association of bactericidal activity of genital tract secretions with Escherichia coli colonization in pregnancy.
MedLine Citation:
PMID:  22867687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Genital tract secretions exhibit bactericidal activity against Escherichia coli. We hypothesized that this defense may be modulated during pregnancy.
STUDY DESIGN: Secretions were collected by vaginal swab from 70 pregnant women (35-37 weeks' gestation) and 35 nonpregnant controls. We mixed E coli with swab eluants or control buffer and colonies enumerated to measure bactericidal activity. Cytokines, chemokines, and antimicrobial peptides were quantified by multiplex or enzyme-linked immunosorbent assay.
RESULTS: Pregnant women had significantly greater bactericidal activity, higher concentrations of proinflammatory cytokines, and lower levels of beta defensins compared to controls. Seven (10%) pregnant and 8 (23%) nonpregnant women were vaginally colonized with E coli; colonization was inversely associated with bactericidal activity.
CONCLUSION: The soluble mucosal immune environment is altered in pregnancy. We speculate that the observed changes may protect against colonization and ascending infection and could provide a biomarker to identify pregnant women at risk for infectious complications including preterm birth.
Authors:
Jeny P Ghartey; Colleen Carpenter; Philip Gialanella; Charlotte Rising; Thomas C McAndrew; Mohak Mhatre; Jessica Tugetman; Mark H Einstein; Cynthia Chazotte; Betsy C Herold
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-07-26
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2012-12-13     Revised Date:  2013-10-17    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  297.e1-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center, Bronx, NY, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chemokines / metabolism*
Cytokines / metabolism*
Escherichia coli / growth & development*
Female
Humans
Pregnancy
Vagina / immunology*,  metabolism
Vaginal Smears
Grant Support
ID/Acronym/Agency:
AI076980/AI/NIAID NIH HHS; AI079763/AI/NIAID NIH HHS; KL2 RR025749/RR/NCRR NIH HHS; R01 AI065309/AI/NIAID NIH HHS; R33 AI079763/AI/NIAID NIH HHS; U19 AI076980/AI/NIAID NIH HHS; UL1 RR025750/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Chemokines; 0/Cytokines
Comments/Corrections

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