Document Detail


Association of bacterial vaginosis, trichomonas vaginalis, and vaginal acidity with outcome of pregnancy.
MedLine Citation:
PMID:  16859053     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Bacterial vaginosis and Trichomons vaginalis are believed to be the risk factors for preterm labor birth and preterm prelabor rupture of membranes. The objective of this study was to investigate the association between bacterial vaginosis, T.vaginalis, and vaginal pH with preterm labor birth and preterm prelabor rupture of membranes after excluding other known risk factors.
METHODS: In this cohort study, we enrolled 1223 pregnant women with gestational age of 16 - 36 weeks from Amir-Almomenin General Hospital in Semnan, Iran, who had no known medical risk factors for preterm labor birth. Bacterial vaginosis and T.vaginalis were determined on the basis of vaginal pH, saline wet mount, and Amsel tests. The principal outcome was delivery before 37 weeks of gestation and preterm prelabor rupture of membranes.
RESULTS: Bacterial vaginosis and T.vaginalis were detected in 16.0% and 5.5% of these women, respectively. Bacterial vaginosis was positive in 65 (33.1%) patients at 16 - 20 weeks of gestation and in 134 (66.9%) patients at 36 weeks of gestation or during labor (developing preterm labor birth or preterm prelabor rupture of membranes). The frequencies for T.vaginalis were 20 (29.9%) and 47 (70.1%) patients, respectively. All patients with bacterial vaginosis and T.vaginalis had a vaginal pH > or = 5. There was a significant correlation between bacterial vaginosis and vaginal pH > or = 5, with preterm labor birth (OR: 5.99; CI: 3.79 - 9.49) and preterm prelabor rupture of membranes (OR: 2.34; CI: 1.07 - 4.99). Moreover, a significant correlation was found between vaginal pH > or = 5 with preterm labor birth (OR: 5.82; CI: 2.96 - 11.39) and preterm prelabor rupture of membranes (OR: 4.11; CI: 1.62 - 10.12). There was no significant correlation between T.vaginalis with preterm labor birth (OR: 0.73; CI: 0.22 - 2.17) and preterm prelabor rupture of membranes (OR: 1.22; CI: 0.29 - 5.05).
CONCLUSION: The presence of bacterial vaginosis or vaginal pH > or = 5 at 16 - 36 weeks of gestation is associated with an increased risk of preterm labor birth and preterm prelabor rupture of membranes.
Authors:
Azam Azargoon; Shohreh Darvishzadeh
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Archives of Iranian medicine     Volume:  9     ISSN:  1029-2977     ISO Abbreviation:  Arch Iran Med     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-11-09     Revised Date:  2013-05-15    
Medline Journal Info:
Nlm Unique ID:  100889644     Medline TA:  Arch Iran Med     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  213-7     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Vali-e-Asr Reproductive Health Research Center, Keshavarz Blvd., Tehran 14194, Iran. valrec2@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Female
Follow-Up Studies
Gestational Age
Humans
Hydrogen-Ion Concentration
Pregnancy
Pregnancy Complications, Infectious*
Pregnancy Outcome*
Retrospective Studies
Risk Factors
Trichomonas Vaginitis / metabolism,  microbiology*
Trichomonas vaginalis / isolation & purification*
Vagina / metabolism*,  microbiology

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