Document Detail


Association of bacteria with hydrocephalus in Ugandan infants. Clinical article.
MedLine Citation:
PMID:  21194290     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
OBJECT: Infantile hydrocephalus in East Africa is predominantly postinfectious. The microbial origins remain elusive, since most patients present with postinfectious hydrocephalus after antecedent neonatal sepsis (NS) has resolved.
METHODS: To characterize this syndrome in Ugandan infants, the authors used polymerase chain reaction targeting bacterial 16S ribosomal DNA from CSF to determine if bacterial residua from recent infections were detectable. Bacteria were identified based on the relationship of genetic sequences obtained with reference bacteria in public databases. The authors evaluated samples from patients presenting during dry and rainy seasons and performed environmental sampling in the villages of patients.
RESULTS: Bacterial DNA was recovered from 94% of patients. Gram-negative bacteria in the phylum Proteobacteria were the most commonly detected. Within this phylum, Gammaproteobacteria dominated in patients presenting after infections during the rainy season, and Betaproteobacteria was most common following infections during the dry season. Acinetobacter species were identified in the majority of patients admitted after rainy season infection.
CONCLUSIONS: Postinfectious hydrocephalus in Ugandan infants appears associated with predominantly enteric gram-negative bacteria. These findings highlight the need for linking these cases with antecedent NS to develop more effective treatment and prevention strategies.
Authors:
Lingling Li; Abinash Padhi; Sylvia L Ranjeva; Sarah C Donaldson; Benjamin C Warf; John Mugamba; Derek Johnson; Zephania Opio; Bhushan Jayarao; Vivek Kapur; Mary Poss; Steven J Schiff
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurosurgery. Pediatrics     Volume:  7     ISSN:  1933-0715     ISO Abbreviation:  J Neurosurg Pediatr     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101463759     Medline TA:  J Neurosurg Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-87     Citation Subset:  IM    
Affiliation:
Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA, USA.
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