Document Detail


Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study.
MedLine Citation:
PMID:  20921080     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To study the association between wheezy symptoms in young children and the presence of bacteria in the airways.
DESIGN: Birth cohort study.
SETTING: Clinical research unit in Copenhagen.
PARTICIPANTS: Children of asthmatic mothers, from age 4 weeks to 3 years, with planned visits and acute admissions to the research clinic.
MAIN OUTCOME MEASURE: Frequency of bacteria and virus carriage in airway aspirates during wheezy episodes and at planned visits without respiratory symptoms.
RESULTS: 984 samples (361 children) were analysed for bacteria, 844 (299 children) for viruses, and 696 (277 children) for both viruses and bacteria. Wheezy episodes were associated with both bacterial infection (odds ratio 2.9, 95% confidence interval 1.9 to 4.3; P<0.001) and virus infection (2.8, 1.7 to 4.4; P<0.001). The associations of bacteria and viruses were independent of each other.
CONCLUSION: Acute wheezy episodes in young children were significantly associated with bacterial infections similar to but independent of the association with virus infections.
Authors:
Hans Bisgaard; Mette Northman Hermansen; Klaus Bønnelykke; Jakob Stokholm; Florent Baty; Nanna Lassen Skytt; Julia Aniscenko; Tatiana Kebadze; Sebastian L Johnston
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-04
Journal Detail:
Title:  BMJ (Clinical research ed.)     Volume:  341     ISSN:  1756-1833     ISO Abbreviation:  BMJ     Publication Date:  2010  
Date Detail:
Created Date:  2010-10-05     Completed Date:  2010-10-13     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  8900488     Medline TA:  BMJ     Country:  England    
Other Details:
Languages:  eng     Pagination:  c4978     Citation Subset:  AIM; IM    
Affiliation:
The Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, and The Danish Pediatric Asthma Centre, Copenhagen University Hospital, Gentofte, Ledreborg Allé 34, DK-2820 Gentofte, Copenhagen, Denmark. Bisgaard@copsac.com
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Bacteria / isolation & purification
Bacterial Infections / microbiology*
Bronchi / microbiology
Bronchial Diseases / microbiology*
Child, Preschool
Humans
Infant
Prospective Studies
Respiratory Sounds / etiology*
Respiratory Tract Infections / microbiology*
Virus Diseases / virology
Viruses / isolation & purification
Comments/Corrections
Comment In:
BMJ. 2010;341:c4836   [PMID:  20921079 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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