Document Detail

Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study.
MedLine Citation:
PMID:  22563029     Owner:  NLM     Status:  Publisher    
OBJECTIVE: This study examined whether vascular alterations are associated with the presence and progression of osteoarthritis of the knee, the hip and the different hand joints in a large prospective cohort study.METHODS: In this population-based study involving participants aged 55 years and older (Rotterdam Study I), men (n=2372) and women (n=3278) were analysed separately. x-Rays of the knee, hip and hand were scored using the Kellgren and Lawrence score for osteoarthritis at baseline, after 6.6 years and 10 years. Measures of atherosclerosis (carotid intima media thickness (IMT) and carotid plaque) and data on covariates (age, body mass index, hypertension, cholesterol ratio, diabetes mellitus and smoking) were collected at baseline. Multivariate logistic regression models with generalised estimated equations were used to calculate OR and corresponding 95% CI. Secondary multiple comparison adjustment resulted in a significance level of p<0.0021.RESULTS: In women, IMT showed an independent association with the prevalence of knee osteoarthritis (adjusted OR (aOR) 1.7, 1.1 to 2.7), and carotid plaque with distal interphalangeal (DIP) osteoarthritis (aOR 1.4, 1.2 to 1.7) and with metacarpophalangeal osteoarthritis (aOR 1.5, 1.1 to 2.2). An independent association for IMT with progression of metacarpophalangeal osteoarthritis was found in women (aOR 2.9, 1.18 to 6.93). Additional adjustment for multiple testing yielded a significant association between carotid plaque and DIP osteoarthritis in women (p<0.001).CONCLUSIONS: This study showed independent associations of atherosclerosis with osteoarthritis of the knee and hand joints in women. The evidence was most solid for a relation with DIP osteoarthritis. More research is needed to confirm the associations and examine the differential association with various joints.
Theun Antonius Hoeven; Maryam Kavousi; Stefan Clockaerts; Hanneke J M Kerkhof; Joyce B van Meurs; Oscar Franco; Albert Hofman; Patrick Bindels; Jacqueline Witteman; Sita Bierma-Zeinstra
Related Documents :
24770089 - Obesity and the risk of preterm birth in patients with cerclage.
2790949 - Prevalence of very severe headache in a large us metropolitan area.
25040979 - No association between traffic density and risk of childhood leukemia: a meta-analysis.
23634329 - Postpartum practices of parturient women in enugu, south east nigeria.
25252039 - Association of bleeding, mortality and sex in acute coronary syndromes: the missing tri...
24075109 - Endovascular repair for ruptured abdominal aortic aneurysm confers an early survival be...
12841419 - Predicting falls in residential care by a risk assessment tool, staff judgement, and hi...
10994179 - Prevalence of sexual abuse history in a sample of women seeking treatment for premenstr...
11405329 - Cigarette smoking, alcohol consumption, and endometrial cancer risk: a population-based...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-6
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  -     ISSN:  1468-2060     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1General Practice, Erasmus University Medical Centre, Rotterdam, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of immunogenicity on the efficacy of long-term treatment of spondyloarthritis with inflixi...
Next Document:  Elaboration and validation of a questionnaire assessing patient expectations about management of kne...