Document Detail

Association of aortic valve sclerosis with thrombin generation in hypertensive patients.
MedLine Citation:
PMID:  18633427     Owner:  NLM     Status:  MEDLINE    
Aortic valve sclerosis (AVS) may predispose to a prothrombotic state, as AVS is predictor of cardiovascular events in hypertensive populations. Thrombin exerts non-thrombotic effects such as vessel tone regulation, progression of atherosclerosis and stimulation of atrial natriuretic peptide (ANP) secretion. We hypothesized that hypertensive patients with AVS may have a persistently activated thrombin generation. We studied 234 asymptomatic never-treated hypertensive patients (73 of them with AVS). Prothrombin F1+2 (F1+2), as a marker of thrombin generation and fibrin D-dimer, as a marker of thrombus formation, ANP and brain natriuretic peptide (BNP) were measured. Presence of AVS, aortic jet velocity and left ventricular diameter at diastole were determined by echocardiography. Glomerular filtration rate was estimated using the Modification of Diet in Renal Disease formula. F1+2 (median and interquartile range (IQR) = 1.05, 0.87-1.38 nM vs. 0.93, 0.72-1.16) and ANP (22, 14-37 pg ml(-1) vs. 17, 11-25) levels were greater, and glomerular filtration rate values (65+/-9 ml min(-1)/1.73 m2 vs. 68+/-11) were lower in hypertensive patients with AVS than in those without AVS. F1+2 (odds ratio, 95% CI = 2.94, 1.07-8.6) was independently associated with AVS after being adjusted for age, gender and the variables of cardiorenal functions measured. After 6 months of treatment using valsartan, F1+2 levels remained elevated in hypertensive patients with AVS (1.14, 0.83-1.42 nM vs. 1.07, 0.84-1.5, n=19), but decreased in those without AVS (1.01, 0.85-1.31 vs. 0.8, 0.84-1.78, n=27). Thrombin generation was associated with AVS in untreated hypertensive patients, and this association was persistent after blood-pressure-lowering treatment using valsartan.
M Iida; M Yamamoto; M Yamazaki; M Sawaguchi; H Honjo; I Kodama; K Kamiya
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-07-17
Journal Detail:
Title:  Journal of human hypertension     Volume:  22     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-16     Completed Date:  2009-01-15     Revised Date:  2009-04-16    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  781-7     Citation Subset:  IM    
Department of Cardiology, Mitsubishi Nagoya Hospital, Nagoya, Aichi, Japan.
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MeSH Terms
Aortic Valve / pathology*,  ultrasonography
Biological Markers / blood
Blood Pressure / physiology
Follow-Up Studies
Heart Valve Diseases / blood,  diagnosis,  etiology*
Heart Ventricles / physiopathology,  ultrasonography
Hypertension / blood*,  complications,  physiopathology
Immunoenzyme Techniques
Middle Aged
Retrospective Studies
Thrombin / metabolism*
Reg. No./Substance:
0/Biological Markers; EC
Comment In:
J Hum Hypertens. 2009 Apr;23(4):287-8   [PMID:  18701926 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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