| Association of aortic valve calcification to the presence, extent, and composition of coronary artery plaque burden: from the Rule Out Myocardial Infarction using Computer Assisted Tomography (ROMICAT) trial. | |
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MedLine Citation:
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PMID: 19781415 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aortic valve calcification (AVC) is associated with cardiovascular risk factors and coronary artery calcification. We sought to determine whether AVC is associated with the presence and extent of overall plaque burden, as well as to plaque composition (calcified, mixed, and noncalcified). METHODS: We examined 357 subjects (mean age 53 +/- 12 years, 61% male) who underwent contrast-enhanced electrocardiogram-gated 64-slice multidetector computed tomography from the ROMICAT trial for the assessment of presence and extent of coronary plaque burden according to the 17-coronary segment model and presence of AVC. RESULTS: Patients with AVC (n = 37, 10%) were more likely than those without AVC (n = 320, 90%) to have coexisting presence of any coronary plaque (89% vs 46%, P < .001) and had a greater extent of coronary plaque burden (6.4 vs 1.8 segments, P < .001). Those with AVC had >3-fold increase odds of having any plaque (adjusted odds ratio [OR] 3.6, P = .047) and an increase of 2.5 segments of plaque (P < .001) as compared to those without AVC. When stratified by plaque composition, AVC was associated most with calcified plaque (OR 5.2, P = .004), then mixed plaque (OR 3.2, P = .02), but not with noncalcified plaque (P = .96). CONCLUSION: Aortic valve calcification is associated with the presence and greater extent of coronary artery plaque burden and may be part of the later stages of the atherosclerosis process, as its relation is strongest with calcified plaque, less with mixed plaque, and nonsignificant with noncalcified plaque. If AVC is present, consideration for aggressive medical therapy may be warranted. |
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Authors:
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Amir A Mahabadi; Fabian Bamberg; Michael Toepker; Christopher L Schlett; Ian S Rogers; John T Nagurney; Thomas J Brady; Udo Hoffmann; Quynh A Truong |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American heart journal Volume: 158 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-09-28 Completed Date: 2009-10-20 Revised Date: 2013-02-06 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 562-8 Citation Subset: AIM; IM |
Affiliation:
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Cardiac MR PET CT Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aortic Valve* Calcinosis / complications, radiography* Coronary Angiography / methods* Coronary Artery Disease / complications, radiography* Female Follow-Up Studies Heart Valve Diseases / complications, radiography* Humans Male Middle Aged Myocardial Infarction / etiology, radiography* Prospective Studies Reproducibility of Results Risk Factors Tomography, X-Ray Computed / methods* |
| Grant Support | |
ID/Acronym/Agency:
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K23 HL098370-03/HL/NHLBI NIH HHS; L30 HL093806-01/HL/NHLBI NIH HHS; R01 HL080053/HL/NHLBI NIH HHS; R01 HL080053-03/HL/NHLBI NIH HHS; T32 HL076136-05/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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