Document Detail

Association of aortic valve calcification to the presence, extent, and composition of coronary artery plaque burden: from the Rule Out Myocardial Infarction using Computer Assisted Tomography (ROMICAT) trial.
MedLine Citation:
PMID:  19781415     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aortic valve calcification (AVC) is associated with cardiovascular risk factors and coronary artery calcification. We sought to determine whether AVC is associated with the presence and extent of overall plaque burden, as well as to plaque composition (calcified, mixed, and noncalcified).
METHODS: We examined 357 subjects (mean age 53 +/- 12 years, 61% male) who underwent contrast-enhanced electrocardiogram-gated 64-slice multidetector computed tomography from the ROMICAT trial for the assessment of presence and extent of coronary plaque burden according to the 17-coronary segment model and presence of AVC.
RESULTS: Patients with AVC (n = 37, 10%) were more likely than those without AVC (n = 320, 90%) to have coexisting presence of any coronary plaque (89% vs 46%, P < .001) and had a greater extent of coronary plaque burden (6.4 vs 1.8 segments, P < .001). Those with AVC had >3-fold increase odds of having any plaque (adjusted odds ratio [OR] 3.6, P = .047) and an increase of 2.5 segments of plaque (P < .001) as compared to those without AVC. When stratified by plaque composition, AVC was associated most with calcified plaque (OR 5.2, P = .004), then mixed plaque (OR 3.2, P = .02), but not with noncalcified plaque (P = .96).
CONCLUSION: Aortic valve calcification is associated with the presence and greater extent of coronary artery plaque burden and may be part of the later stages of the atherosclerosis process, as its relation is strongest with calcified plaque, less with mixed plaque, and nonsignificant with noncalcified plaque. If AVC is present, consideration for aggressive medical therapy may be warranted.
Amir A Mahabadi; Fabian Bamberg; Michael Toepker; Christopher L Schlett; Ian S Rogers; John T Nagurney; Thomas J Brady; Udo Hoffmann; Quynh A Truong
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American heart journal     Volume:  158     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2009-10-20     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  562-8     Citation Subset:  AIM; IM    
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MeSH Terms
Aortic Valve*
Calcinosis / complications,  radiography*
Coronary Angiography / methods*
Coronary Artery Disease / complications,  radiography*
Follow-Up Studies
Heart Valve Diseases / complications,  radiography*
Middle Aged
Myocardial Infarction / etiology,  radiography*
Prospective Studies
Reproducibility of Results
Risk Factors
Tomography, X-Ray Computed / methods*
Grant Support
K23 HL098370/HL/NHLBI NIH HHS; L30 HL093806/HL/NHLBI NIH HHS; L30 HL093806-01/HL/NHLBI NIH HHS; R01 HL080053/HL/NHLBI NIH HHS; R01 HL080053-03/HL/NHLBI NIH HHS; T32 HL076136/HL/NHLBI NIH HHS; T32 HL076136-05/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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