Document Detail


Association of antenatal steroid use with cord blood immune biomarkers in preterm births.
MedLine Citation:
PMID:  21576006     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To evaluate the effect of maternal administration of antenatal steroids (ANS) on cord blood cytokine levels at birth in preterm infants.
METHODS: Cord blood cytokine concentrations were measured for pro-inflammatory cytokines (IL-1β, IL-6, and IL-8); anti-inflammatory cytokines (IL-4, IL-10 and TGF-β); and neurotrophic cytokines (BDNF, NT-3, and NT-4) in two hundred preterm infants. Data were analyzed using multivariable linear regression to model the independent and joint effects of ANS and inflammation on mean log cord blood cytokine concentrations adjusted for gestational age and Apgar scores.
RESULTS: Exposure to ANS had no significant effect on the cord blood concentrations of cytokines measured in this study. All three pro-inflammatory cytokine levels and levels of IL-10 were significantly increased and cord blood levels of TGF-β and NT-3 were significantly decreased in infants with placental inflammation.
CONCLUSION: Although exposure to ANS did not have any significant effect on cord blood levels of cytokines, there was a trend toward the attenuation of inflammatory response and higher levels of neurotrophic cytokines in infants born to mothers with placental inflammation and exposure to ANS compared to infants born to mothers with placental inflammation and no ANS exposure.
Authors:
Praveen Kumar; Scott A Venners; Lingling Fu; Colleen Pearson; Katherin Ortiz; Xiaobin Wang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-05-14
Journal Detail:
Title:  Early human development     Volume:  87     ISSN:  1872-6232     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-20     Completed Date:  2011-11-15     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  559-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. p-kumar@northwestern.edu
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / blood*
Cytokines / blood*
Female
Fetal Blood / chemistry*
Gestational Age
Humans
Infant, Newborn
Infant, Premature / immunology*
Inflammation / blood
Interleukin-10 / blood
Male
Pregnancy
Prenatal Care
Steroids / administration & dosage*
Transforming Growth Factor beta / blood
Grant Support
ID/Acronym/Agency:
R01 HD041702-09/HD/NICHD NIH HHS; R01 HD41702/HD/NICHD NIH HHS; R21 ES011666-04/ES/NIEHS NIH HHS; R21ES11666/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/Steroids; 0/Transforming Growth Factor beta; 130068-27-8/Interleukin-10
Comments/Corrections

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