Document Detail


Association of angiotensin converting enzyme and angiotensin type 2 receptor gene polymorphisms with renal damage in posterior urethral valves.
MedLine Citation:
PMID:  20149750     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To examine the association with renal damage in patients with posterior urethral valves (PUV) of two renin-angiotensin system gene polymorphisms: angiotensin converting enzyme insertion/deletion (ACE I/D) and angiotensin type 2 receptor (AT2R A1332G), PATIENTS AND METHODS: In 120 patients with PUV, after stabilization, transurethral fulguration or a Blocksom vesicostomy was performed. Records were reviewed for age at diagnosis, biochemical renal function at diagnosis, results of urine cultures, voiding cystourethrograms, radiologic, sonographic and nuclear medicine scan findings, and follow-up data. ACE I/D genotypes were determined by the polymerase chain reaction using allele specific primers.
RESULTS: The frequency of the ACE DD genotype was significantly higher in patients with chronic kidney disease (P=0.02) and renal scarring (P=0.05). These genotypes were also associated with a statistically higher incidence of vesicoureteral reflux, diurnal incontinence, proteinuria and hypertension. A significantly higher frequency of the AT2R GG genotype was found in PUV patients as compared to healthy unrelated control subjects (P=0.001), and in PUV patients with scarring (P=0.02).
CONCLUSION: The ACE DD and AT2R GG genotypes are associated with chronic kidney disease and scarring in PUV patients. The GG genotype incidence is higher among PUV patients compared to the control population, and further studies in this area may help understanding of the genetic basis of PUV.
Authors:
Narasimhan Kannan Laksmi; Kannan Laksmi Narasimhan; Madhu Khullar; Khullar Madhu; Balpinder Kaur; Kaur Balpinder; Monica Ahuja; Ahuja Monica; Jai Kumar Mahajan; Mahajan Jai Kumar; Bhagwant Rai Mittal; Mittal Bhagwant Rai; Anish Bhattacharya; Bhattacharya Anish; Bikash Medhi; Medhi Bikash
Publication Detail:
Type:  Journal Article     Date:  2010-02-10
Journal Detail:
Title:  Journal of pediatric urology     Volume:  6     ISSN:  1873-4898     ISO Abbreviation:  J Pediatr Urol     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-10-26     Completed Date:  2011-02-10     Revised Date:  2012-01-09    
Medline Journal Info:
Nlm Unique ID:  101233150     Medline TA:  J Pediatr Urol     Country:  England    
Other Details:
Languages:  eng     Pagination:  560-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Department of Pediatric Surgery, Post Graduate Medical Institute (PGIMER), Chandigarh 160012, India. narasimhankl@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Chronic Disease
Cicatrix / complications,  pathology
Gene Frequency
Genotype
Humans
Hydronephrosis / complications
Infant
Infant, Newborn
Kidney Diseases / complications,  genetics*,  pathology
Male
Peptidyl-Dipeptidase A / genetics*
Polymorphism, Genetic*
Receptor, Angiotensin, Type 2 / genetics*
Urethra / abnormalities*
Vesico-Ureteral Reflux / complications
Chemical
Reg. No./Substance:
0/Receptor, Angiotensin, Type 2; EC 3.4.15.1/Peptidyl-Dipeptidase A
Comments/Corrections
Erratum In:
J Pediatr Urol. 2011 Dec;7(6):e1
Note: Narasimhan, Kannan Laksmi [corrected to Laksmi, Narasimhan Kannan]; Madhu, Khullar [corrected to Khullar, Madhu]; Balpinder, Kaur [corrected to Kaur, Balpinder]; Monica, Ahuja [corrected to Ahuja, Monica]; Kumar, Mahajan Jai [corrected to Mahajan, Jai Kumar]; Rai, Mittal Bhagwant [corrected to Mittal, Bhagwant Rai]; Anish, Bhattacharya [corrected to Bhattacharya, Anish]; Bikash, Medhi [corrected to Medhi, Bikash]

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