Document Detail


Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with decreased risk for basal cell carcinoma.
MedLine Citation:
PMID:  23299466     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The incidence of basal cell carcinoma (BCC) is significantly reduced in individuals treated with inhibitors of angiotensin I-converting enzyme (ACE) that produces angiotensin II. The objective of this study was to investigate the possible association of a functional polymorphism in the ACE gene, which affects its transcription, with risk for BCC. In DNA samples of 92 patients with BCC and 103 healthy controls of Greek origin and comparable age and gender, we studied the ACE gene insertion/deletion (I/D) polymorphism. Fisher's exact test was used for comparison of allele and genotype frequencies between the control and patients' groups. The detected low expression I allele frequency in the group of BCC patients was significantly decreased compared to controls (15.8 vs. 31.1 %, respectively; P = 0.001). ID heterozygotes exhibited 3.06 times lower BCC risk, compared with DD homozygotes (P = 0.001; OR = 0.327, 95 % CI = 0.174-0.615). The protective role of I allele was particularly prominent in women (P = 0.007, OR = 0.299, 95 % CI = 0.125-0.716), while for men it exhibited a marginal level (P = 0.041). These findings indicate that the low expression ACE I allele carriers have a decreased risk for BCC. The protective effect of the ID genotype against BCC may be explained by a possible underlying mechanism involving the effect of produced angiotensin II levels on its receptors due to putatively different binding affinity.
Authors:
Christos Yapijakis; Nikolas Koronellos; Sofia Spyridonidou; Antonis Vylliotis; Dimitris Avgoustidis; Nikolaos Goutas; Dimitris Vlachodimitropoulos; Eleftherios Vairaktaris
Related Documents :
24138066 - Microcephaly, epilepsy, and neonatal diabetes due to compound heterozygous mutations in...
24002866 - Genetic background and gxe interactions modulate the penetrance of a naturally occurrin...
23506506 - Haplotype structure, adaptive history and associations with exploratory behaviour of th...
23369106 - Snpranker 2.0: a gene-centric data mining tool for diseases associated snp prioritizati...
11310586 - Multiple single-nucleotide polymorphisms (snps) in the japanese population in six candi...
17956396 - Effective population size associated with self-fertilization: lessons from temporal cha...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Archives of dermatological research     Volume:  -     ISSN:  1432-069X     ISO Abbreviation:  Arch. Dermatol. Res.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000462     Medline TA:  Arch Dermatol Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Oral and Maxillofacial Surgery, University of Athens Medical School, "Attikon" Hospital, Rimini 1, 12461, Athens, Greece, cyapijakis_ua_gr@yahoo.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Pharmacokinetics, Pharmacodynamics and Physiologically-Based Pharmacokinetic Modelling of Monoclonal...
Next Document:  Tuning the surface plasmon resonance of silver nanoclusters by oxygen exposure and low-energy plasma...