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Association of angiotensin-converting enzyme gene insertion/deletion polymorphism with polycystic ovary syndrome: a meta-analysis.
MedLine Citation:
PMID:  22791704     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION: Epidemiological studies investigating the association of angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism with polycystic ovary syndrome (PCOS) produced inconsistent results. To derive a more precise estimation of the relationship between I/D polymorphism and PCOS, we conducted the current meta-analysis. MATERIALS AND METHODS: PubMed, Web of Science and CNKI were searched for eligible publications up to 1 February 2012. The association was evaluated under different genetic models. RESULTS: Six studies with 1451 cases and 773 controls were finally included in our meta-analysis. The results showed that no significant association between I/D polymorphism and PCOS was observed in the overall population. However, in subgroup analyses stratified by ethnicity, significant association was observed in Caucasians (OR = 1.48, 95% CI, 1.00-2.19 for D vs. I; OR = 1.61, 95% CI, 1.14-2.27 for DD vs. II; OR = 1.43, 95% CI, 1.04-1.97 for DD and DI vs. II), but not in Asians. CONCLUSIONS: Our meta-analysis suggested that the ACE I/D polymorphism was associated with increased risk of PCOS in Caucasians, but not in Asians. However, considering that the conclusions were based on a relatively small sample size, larger studies involving various ethnic populations should be warranted in future studies to validate our findings.
Authors:
Hongxia Jia; Bin Wang; Lili Yu; Zhaoshun Jiang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-12
Journal Detail:
Title:  Journal of the renin-angiotensin-aldosterone system : JRAAS     Volume:  -     ISSN:  1752-8976     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100971636     Medline TA:  J Renin Angiotensin Aldosterone Syst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Endocrinology and Metabolism, The General Hospital of Jinan Military Command, China.
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