Document Detail


Association analysis of the polymorphisms of the VDR gene with bone mineral density and the occurrence of fractures.
MedLine Citation:
PMID:  17704996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Associations of the FokI, BsmI, ApaI, and TaqI polymorphisms of the vitamin D receptor (VDR) gene with the bone mineral density (BMD) of the lumbar part of the spinal column (BMD LS) and the neck of the femur (BMD FN), and with the occurrence of fractures, were studied using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis on DNA isolated from peripheral blood of 239 women and 40 men from the region of western Poland. Three polymorphisms of the 3' end of the VDR gene (BsmI, ApaI, TaqI) indicated a strong linkage disequilibrium. Association analysis of the VDR gene FokI polymorphism with BMD LS showed a dose effect of allele f. The association of the bAT haplotype of the BsmI, ApaI, and TaqI polymorphisms of the VDR gene with BMD FN was statistically significant. The association of the ApaI polymorphism with the occurrence of fractures was observed. Associations were also observed between the occurrence of fractures and the baT haplotypes of the VDR gene.
Authors:
Wanda Horst-Sikorska; Robert Kalak; Anna Wawrzyniak; Michalina Marcinkowska; Liliana Celczynska-Bajew; Ryszard Slomski
Related Documents :
17919546 - Effect of miglustat on bone disease in adults with type 1 gaucher disease: a pooled ana...
17955276 - Tai chi for osteoporosis: a systematic review.
19833006 - Measuring metacarpal cortical bone by digital x-ray radiogrammetry: a step forward?
15671096 - Voluntary weight reduction in older men increases hip bone loss: the osteoporotic fract...
18971686 - Nasal reconstruction with local flaps: a simple algorithm for management of small defects.
16482586 - Beauty of skin-grafted free muscle flaps in head and neck reconstruction.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-25
Journal Detail:
Title:  Journal of bone and mineral metabolism     Volume:  25     ISSN:  0914-8779     ISO Abbreviation:  J. Bone Miner. Metab.     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-20     Completed Date:  2007-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436705     Medline TA:  J Bone Miner Metab     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  310-9     Citation Subset:  IM    
Affiliation:
Department of Family Medicine, University of Medical Sciences, Poznan, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Bone Density / genetics*
Female
Fractures, Bone / genetics*
Genotype
Haplotypes
Humans
Linkage Disequilibrium / genetics
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Genetic*
Polymorphism, Restriction Fragment Length
Receptors, Calcitriol / genetics*
Chemical
Reg. No./Substance:
0/Receptors, Calcitriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Factors affecting long-term compliance of osteoporotic patients with bisphosphonate treatment and QO...
Next Document:  Genetic association of a polymorphism of the cAMP-responsive element binding protein-binding protein...