Document Detail


Association analysis of Toll-like receptor 4 polymorphisms with autoimmune pancreatitis.
MedLine Citation:
PMID:  19500628     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Autoimmune pancreatitis (AIP) is characterized by lymphoplasmocytic inflammation, high serum IgG4 concentrations, and a favorable response to corticosteroid treatment. Although long-term follow-up studies have shown that a relapse rate of 30-40% can occur in AIP after remission with corticosteroids, there are few genetic characteristic predictors of relapse in AIP patients. Toll-like receptor (TLR) is an important mediator in both innate and adaptive immunity. Polymorphisms in TLR4 gene have been linked with several autoimmune and allergic diseases. We therefore investigated the genetic association between TLR4 polymorphisms and AIP susceptibility and relapse in a Japanese population. Eight SNPs in TLR4 (rs10759930, rs1927914, rs1927911, rs12377632, rs2149356, rs11536889, rs7037117, and rs7045953) were genotyped in 59 patients with AIP and 126 healthy controls using a TaqMan assay. Analysis of allelic frequencies revealed no statistical association with either susceptibility or relapse of AIP. These data indicate that TLR4 polymorphisms do not play an important role in the development of AIP.
Authors:
Takeji Umemura; Yoshihiko Katsuyama; Hideaki Hamano; Kei Kitahara; Mari Takayama; Norikazu Arakura; Shigeyuki Kawa; Eiji Tanaka; Masao Ota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-06-18
Journal Detail:
Title:  Human immunology     Volume:  70     ISSN:  1879-1166     ISO Abbreviation:  Hum. Immunol.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-24     Completed Date:  2010-02-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8010936     Medline TA:  Hum Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  742-6     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Division of Gastroenterology and Hepatology, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Autoimmune Diseases / diagnosis,  epidemiology,  genetics*,  immunology,  physiopathology
Biological Markers / metabolism
Case-Control Studies
DNA Mutational Analysis
Female
Follow-Up Studies
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Japan
Male
Middle Aged
Pancreatitis / diagnosis,  epidemiology,  genetics*,  immunology,  physiopathology
Polymorphism, Single Nucleotide
Prognosis
Recurrence
Toll-Like Receptor 4 / genetics*,  immunology,  metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/TLR4 protein, human; 0/Toll-Like Receptor 4

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