Document Detail


Association analysis of the PTPN22 gene in childhood-onset systemic lupus erythematosus in Mexican population.
MedLine Citation:
PMID:  17066073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several studies have identified a functional single nucleotide polymorphism 1858C/T in the PTPN22 gene to be associated with several autoimmune diseases. Association studies of this polymorphism with familial and sporadic systemic lupus erythematosus (SLE) have shown some discrepancies. To our knowledge, this is the first study that includes only pediatric-onset SLE patients. We performed a case-control association study in 250 unrelated Mexican patients with childhood-onset SLE consisting of 228 cases with sporadic SLE and 22 cases with familial SLE and 355 healthy controls. We observed a statistically significant difference in the frequency of the PTPN22 1858T allele between SLE patients (3.4%) and healthy controls (1.1%) (P=0.0062, odds ratio (OR) 3.09 (95% confidence interval 1.32-7.21)). The association was also observed when only sporadic cases were analyzed (OR=3.19). Our results support the association of the PTPN22 1858T allele with sporadic childhood-onset SLE in Mexican population.
Authors:
V Baca; R Velázquez-Cruz; G Salas-Martínez; F Espinosa-Rosales; Y Saldaña-Alvarez; L Orozco
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-26
Journal Detail:
Title:  Genes and immunity     Volume:  7     ISSN:  1466-4879     ISO Abbreviation:  Genes Immun.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-06     Completed Date:  2007-02-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100953417     Medline TA:  Genes Immun     Country:  England    
Other Details:
Languages:  eng     Pagination:  693-5     Citation Subset:  IM    
Affiliation:
Department of Rheumatology, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS, Mexico City, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Case-Control Studies
Child
Female
Gene Frequency
Genetic Predisposition to Disease*
Humans
Lupus Erythematosus, Systemic / genetics*
Male
Mexico
Polymorphism, Single Nucleotide / genetics
Protein Tyrosine Phosphatase, Non-Receptor Type 22
Protein Tyrosine Phosphatases / genetics*
Chemical
Reg. No./Substance:
EC 3.1.3.48/PTPN22 protein, human; EC 3.1.3.48/Protein Tyrosine Phosphatase, Non-Receptor Type 22; EC 3.1.3.48/Protein Tyrosine Phosphatases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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