| Association among serum fetuin-A level, coronary artery calcification, and bone mineral densitometry in maintenance hemodialysis patients. | |
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MedLine Citation:
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PMID: 19681840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with end-stage renal disease have a very high prevalence and extent of arterial calcification. A number of studies suggest that similar pathophysiologic mechanisms are responsible for development and progression of calcification of atherosclerotic plaque and bone formation. Fetuin-A is a potent calcification inhibitor and is expressed in bone, with not-yet well-defined functions. The aim of this study was to investigate the relation between bone mineral densitometry parameters, coronary artery calcification, and serum fetuin-A levels. In a cross-sectional design, we included 72 maintenance hemodialysis (HD) patients and 30 age- and gender-matched healthy controls. Serum fetuin-A levels were studied both in maintenance HD patients and healthy controls. Maintenance HD patients had radius, hip, and lumbar spine bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry and coronary artery calcification score (CACS) measured by electron-beam computed tomography. The associations between site-specific BMD parameters, CACS, and serum fetuin-A levels were studied in maintenance HD patients. CACS, mass, and volume of plaques in coronary arteries were significantly higher in patients with a T-score below -2.5 than above in the proximal region of the radius, neck and trochanter of the femur, and the lumbar spine. Mean serum fetuin-A concentration was 0.636 +/- 0.118 g/L in maintenance HD patients and it was less than healthy controls (0.829 +/- 0.100 g/L, P < 0.0001). CACS, mass, and volume of plaques in coronary arteries correlated significantly with the serum fetuin-A levels. Moreover, significant positive correlations were shown between the serum fetuin-A levels, BMD values, and T-scores of proximal radius, neck, and trochanter of the femur, but not with the lumbar spine. The present study demonstrates an association between serum fetuin-A levels, coronary artery calcification, and bone mineral densities--except for the lumbar spine, in maintenance HD patients. However, the results should be interpreted with caution because of the cross-sectional design of the study. |
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Authors:
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Alper Kirkpantur; Bulent Altun; Tuncay Hazirolan; Deniz Akata; Mustafa Arici; Serafettin Kirazli; Cetin Turgan |
Publication Detail:
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Type: Journal Article Date: 2009-07-22 |
Journal Detail:
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Title: Artificial organs Volume: 33 ISSN: 1525-1594 ISO Abbreviation: Artif Organs Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-23 Completed Date: 2010-01-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 844-54 Citation Subset: IM |
Affiliation:
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Departments of Internal Medicine, Nephrology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey. alperkirkpantur@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adult Aged Biological Markers / blood Blood Proteins / analysis* Bone Density* Calcinosis / blood, etiology*, radiography Case-Control Studies Coronary Artery Disease / blood, etiology*, radiography Cross-Sectional Studies Female Hip Joint / radiography Humans Kidney Failure, Chronic / blood, complications, radiography, therapy* Lumbar Vertebrae / radiography Male Middle Aged Proportional Hazards Models Radius / radiography Renal Dialysis* Risk Assessment Risk Factors Severity of Illness Index Tomography, X-Ray Computed |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Blood Proteins; 0/alpha2HS glycoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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