Document Detail

Association among serum fetuin-A level, coronary artery calcification, and bone mineral densitometry in maintenance hemodialysis patients.
MedLine Citation:
PMID:  19681840     Owner:  NLM     Status:  MEDLINE    
Patients with end-stage renal disease have a very high prevalence and extent of arterial calcification. A number of studies suggest that similar pathophysiologic mechanisms are responsible for development and progression of calcification of atherosclerotic plaque and bone formation. Fetuin-A is a potent calcification inhibitor and is expressed in bone, with not-yet well-defined functions. The aim of this study was to investigate the relation between bone mineral densitometry parameters, coronary artery calcification, and serum fetuin-A levels. In a cross-sectional design, we included 72 maintenance hemodialysis (HD) patients and 30 age- and gender-matched healthy controls. Serum fetuin-A levels were studied both in maintenance HD patients and healthy controls. Maintenance HD patients had radius, hip, and lumbar spine bone mineral density (BMD) assessed by dual-energy X-ray absorptiometry and coronary artery calcification score (CACS) measured by electron-beam computed tomography. The associations between site-specific BMD parameters, CACS, and serum fetuin-A levels were studied in maintenance HD patients. CACS, mass, and volume of plaques in coronary arteries were significantly higher in patients with a T-score below -2.5 than above in the proximal region of the radius, neck and trochanter of the femur, and the lumbar spine. Mean serum fetuin-A concentration was 0.636 +/- 0.118 g/L in maintenance HD patients and it was less than healthy controls (0.829 +/- 0.100 g/L, P < 0.0001). CACS, mass, and volume of plaques in coronary arteries correlated significantly with the serum fetuin-A levels. Moreover, significant positive correlations were shown between the serum fetuin-A levels, BMD values, and T-scores of proximal radius, neck, and trochanter of the femur, but not with the lumbar spine. The present study demonstrates an association between serum fetuin-A levels, coronary artery calcification, and bone mineral densities--except for the lumbar spine, in maintenance HD patients. However, the results should be interpreted with caution because of the cross-sectional design of the study.
Alper Kirkpantur; Bulent Altun; Tuncay Hazirolan; Deniz Akata; Mustafa Arici; Serafettin Kirazli; Cetin Turgan
Publication Detail:
Type:  Journal Article     Date:  2009-07-22
Journal Detail:
Title:  Artificial organs     Volume:  33     ISSN:  1525-1594     ISO Abbreviation:  Artif Organs     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-23     Completed Date:  2010-01-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  844-54     Citation Subset:  IM    
Departments of Internal Medicine, Nephrology Unit, Hacettepe University Faculty of Medicine, Ankara, Turkey.
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MeSH Terms
Absorptiometry, Photon
Biological Markers / blood
Blood Proteins / analysis*
Bone Density*
Calcinosis / blood,  etiology*,  radiography
Case-Control Studies
Coronary Artery Disease / blood,  etiology*,  radiography
Cross-Sectional Studies
Hip Joint / radiography
Kidney Failure, Chronic / blood,  complications,  radiography,  therapy*
Lumbar Vertebrae / radiography
Middle Aged
Proportional Hazards Models
Radius / radiography
Renal Dialysis*
Risk Assessment
Risk Factors
Severity of Illness Index
Tomography, X-Ray Computed
Reg. No./Substance:
0/Biological Markers; 0/Blood Proteins; 0/alpha2HS glycoprotein

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