| Association among low whole blood viscosity, haematocrit, haemoglobin and diabetic retinopathy in subjects with type 2 diabetes. | |
| | |
MedLine Citation:
|
PMID: 20530659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: Haemorheological variables influence endothelial function through the release of several factors. Clinical studies have described an association among blood viscosity, haematocrit, haemoglobin and macro-angiopathy. Few data are reported about the association between haemorheological variables and micro-angiopathy. The aim of the present study was to evaluate the association between these variables and retinopathy in subjects with type 2 diabetes. METHODS: 111 men, 79 postmenopausal women, and 95 healthy age- and sex-matched controls were recruited. Haematocrit and haemoglobin were measured by standard methods. Blood viscosity was calculated according to the formula (0.12× haematocrit)+(0.17× (plasma proteins-2.07)). Subjects were grouped according to the presence or absence of diabetic retinopathy, while the severity of retinopathy was classified according to the Early Treatment Diabetic Retinopathy Study scale. RESULTS: Haemoglobin, haematocrit and whole blood viscosity were significantly lower in subjects with retinopathy compared to subjects without retinopathy in both sexes. These variables significantly decreased with increasing severity of retinopathy. A multiple logistic regression analysis confirmed the independent inverse association among viscosity, haematocrit, haemoglobin and retinopathy (p<0.01). CONCLUSION: Results demonstrate the association among low viscosity, haemoglobin, haematocrit and diabetic retinopathy. The mechanisms responsible for this association can be hypothesised. Reduced haemoglobin might cause direct organ damage. Low blood viscosity, through the reduction of shear stress, might inhibit the anti-atherogenic functions of endothelial cells. |
| | |
Authors:
|
C Irace; F Scarinci; V Scorcia; D Bruzzichessi; R Fiorentino; G Randazzo; G Scorcia; A Gnasso |
Related Documents
:
|
11757809 - Static perimetry and diabetic retinopathy: a long-term follow-up. 402299 - An audio urine-glucose analyzer for blind diabetics. 2970919 - Reduced venous compliance and increased transcapillary escape of protein in insulin-dep... 17935059 - Diabetic retinopathy: treatment and prevention. 14618419 - A hemochromatosis-causing mutation c282y is a risk factor for proliferative diabetic re... 19825149 - Absence of diabetic retinopathy in a patient who has had diabetes mellitus for 69 years... 12455389 - Association of diabetic maculopathy with diabetic nephropathy--a study. 9452129 - Experimental use of raffinose as an osmotic agent for peritoneal dialysis. 12754699 - Role of family in the management of type-i diabetes: an indian experience. |
Publication Detail:
|
Type: Journal Article Date: 2010-06-08 |
Journal Detail:
|
Title: The British journal of ophthalmology Volume: 95 ISSN: 1468-2079 ISO Abbreviation: Br J Ophthalmol Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-17 Completed Date: 2011-03-25 Revised Date: 2011-08-08 |
Medline Journal Info:
|
Nlm Unique ID: 0421041 Medline TA: Br J Ophthalmol Country: England |
Other Details:
|
Languages: eng Pagination: 94-8 Citation Subset: IM |
Affiliation:
|
Department of Clinical and Experimental Medicine G. Salvatore, University Magna Græcia of Catanzaro, Catanzaro, Italy. irace@unicz.it |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Anemia / blood*, complications Blood Viscosity / physiology* Case-Control Studies Diabetes Mellitus, Type 2 / blood* Diabetic Retinopathy / blood* Female Hematocrit Hemoglobins Humans Male Middle Aged Risk Factors |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobins |
| Comments/Corrections | |
Comment In:
|
Br J Ophthalmol. 2011 Jul;95(7):1028; author reply 1028
[PMID:
21436179
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of low-density lipoprotein apheresis on ocular microcirculation in patients with hypercho...
Next Document: A new method to prevent loss of mitomycin C soaked sponges under the conjunctiva during trabeculecto...