Document Detail


Association of alpha1A adrenergic receptor gene variants on chromosome 8p21 with human stage 2 hypertension.
MedLine Citation:
PMID:  16685204     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE AND DESIGN: We previously reported a significant linkage between human chromosome 8p22 with essential hypertension and systolic blood pressure levels. On the basis of this, we used an efficient age, sex and area-matched case-control scheme to test the association of the polymorphisms in the human alpha1A adrenergic receptor (ADRA1A) gene, located on chromosome 8p21-p11.2, with essential hypertension in a northern Han Chinese population. METHODS: Seven polymorphisms were identified by direct sequencing of genomic DNA derived from 48 randomly recruited hypertensive and 48 healthy subjects. They were also examined for association with essential hypertension in 480 stage 2 hypertensive individuals and their individually matched controls. RESULTS: We observed significantly higher frequencies of the 347Arg allele and 2547G alleles in the cases compared with their controls (P = 0.04 and 0.007, respectively). McNemar's test revealed that carriers of 2547G alleles were at a greater risk of essential hypertension with an odds ratio of 3.00 [95% confidence interval (CI) 1.23-8.35]. We then performed a conditional logistic regression to adjust the effects of conventional risk factors, revealing an odds ratio of 2.84 for carriers of the 2547G allele (95% CI 1.15-6.99). With the haplotypic probabilities estimated using PHASE software, we performed haplotype trend regression analysis, showing a significant association between haplotype 7 and essential hypertension (P = 0.02), after adjustment for conventional risk factors. CONCLUSIONS: Our findings suggest that the genetic variations in the ADRA1A gene are significantly associated with essential hypertension, and may play an important role in the development of essential hypertension in this Chinese population.
Authors:
Dongfeng Gu; Dongliang Ge; Harold Snieder; Jiang He; Shufeng Chen; Jianfeng Huang; Biao Li; Runsheng Chen; Boqin Qiang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  24     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-05-10     Completed Date:  2006-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1049-56     Citation Subset:  IM    
Affiliation:
Division of Population Genetics and Prevention, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. gudf@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
China
Chromosomes, Human, Pair 8 / genetics
Female
Haplotypes
Health Status
Humans
Hypertension / genetics*
Linkage Disequilibrium
Male
Middle Aged
Polymorphism, Single Nucleotide
Receptors, Adrenergic, alpha-1 / genetics*
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, alpha-1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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