Document Detail


Association of alpha-adducin Gly460Trp polymorphism with coronary artery disease in a Korean population.
MedLine Citation:
PMID:  17984662     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Coronary artery disease is caused by multiple genetic and environmental factors. The disease is also closely associated with cardiovascular conditions such as hypertension. In order to investigate any possible role of hypertension candidate genes in the disease development and progression, we examined the association of the polymorphisms of 31 hypertension candidate genes with coronary artery disease. METHODS: Genetic polymorphisms of 31 hypertension candidate genes were initially screened by resequencing DNA samples from 24 unrelated individuals in a Korean population. Association analysis was performed using 1284 unrelated Korean men, including 749 coronary artery disease subjects and 535 normal healthy controls. RESULTS: We identified a total of 409 single nucleotide polymorphisms including 40 nonsynonymous single nucleotide polymorphisms, 32 insertions/deletions and four microsatellites. Among 40 nonsynonymous single nucleotide polymorphisms, 29 were examined for an association with coronary artery disease. A significant association with coronary artery disease was observed in a polymorphism of the ADD1 gene (Gly460Trp; +29017G/T) (odds ratio 0.71-0.81; P = 0.01-0.04). The same polymorphism was also associated with the number of arteries with significant coronary artery stenosis in the coronary artery disease patients (P = 0.01) as well as the increase in systolic blood pressure (P = 0.02). CONCLUSIONS: The ADD1 Gly460Trp polymorphism is significantly associated with an increased risk of coronary artery disease as well as blood pressure, indicating that ADD1 plays a role in the pathogenesis of coronary artery disease as well as hypertension.
Authors:
Seung-Hun Cha; Hung-Tae Kim; Yangsoo Jang; Sungha Park; Jae-Jung Kim; Min Young Song; Jin-Hyoung Park; Ha-Jung Ryu; Hyun-Young Park; Sung-Joo Kim Yoon; Kuchan Kimm; Jong-Keuk Lee; Bermseok Oh
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  25     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-06     Completed Date:  2008-01-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  2413-20     Citation Subset:  IM    
Affiliation:
National Genome Research Institute, National Institute of Health, Seoul, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Amino Acid Substitution
Calmodulin-Binding Proteins / genetics*
Case-Control Studies
Chromosome Mapping
Chromosomes, Human, Pair 4 / genetics
Coronary Artery Disease / etiology,  genetics*,  pathology
Gene Frequency
Genotype
Humans
Hypertension / etiology,  genetics
Korea
Male
Middle Aged
Polymorphism, Single Nucleotide*
Risk Factors
Chemical
Reg. No./Substance:
0/Calmodulin-Binding Proteins; 0/adducin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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