Document Detail


Association of alkaline phosphatase with acute myocardial infarction in a population with high prevalence of hypovitaminosis D.
MedLine Citation:
PMID:  23954837     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Since Pakistanis have high prevalence of hypovitaminosis-D as well as acute myocardial infarction (AMI), the objective of the study was to investigate the relationship between vitamin-D deficiency and risk of AMI in a hospital-based population and to identify major risk factors for this disease.
METHODS: Fasting serum samples from 66 consecutive AMI patients [age 30-70 y] and 132 gender and age-matched (within 5 y) healthy controls were analyzed for concentrations of glucose, total-cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides, calcium, inorganic phosphate, alkaline phosphatase (ALP), bone-ALP, parathyroid hormone (PTH), 25(OH) vitamin-D (25(OH)D) and alanine aminotransferase.
RESULTS: Mean concentrations of serum 25(OH)D, PTH, total-ALP, bone-ALP, LDL-cholesterol, HDL-cholesterol and glucose were significantly different compared to healthy controls (p<0.05). Percent vitamin-D deficiency/insufficiency (levels <30ng/ml) was significantly greater in AMI patients compared to controls (93.9% vs.75.8%; p=0.001). Multiple conditional logistic regression analysis revealed that increased levels of 25(OH)D were associated with decreased risk of AMI [MAOR(95% CI)=0.821(0.718, 0.940); p=0.004]. Hypertension and smoking were positively associated with AMI.
CONCLUSIONS: Increased vitamin-D levels were associated with decreased risk of AMI, while serum glucose, bone-ALP, hypertension and smoking were positively associated with it. Association of bone-ALP with AMI in hypovitaminosis-D is a novel finding of this study.
Authors:
Mohammad Perwaiz Iqbal; Naseema Mehboobali; Iqbal Azam; Asal Khan Tareen
Related Documents :
493287 - Juvenile-onset obesity and deficits in caloric regulation in msg-treated rats.
21257657 - Monitoring adherence to drug treatment by using change in cholesterol concentration: se...
23808777 - Dietary glycemic index, glycemic load, and cardiovascular disease risk factors: tehran ...
15798947 - The effect of a high-carbohydrate meal on postprandial thermogenesis and sympathetic ne...
1934187 - Effect of molecular weight in amphipathic polyethyleneglycol on prolonging the circulat...
20861277 - Deficits in gastrointestinal responses controlling food intake and body weight.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-8-15
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-8-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013.
Affiliation:
Departments of Biological and Biomedical Sciences, Aga Khan University, Karachi-74800, Pakistan. Electronic address: perwaiz.iqbal@aku.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Reference Intervals of D-dimer during the pregnancy and puerperium period on the STAR-R Evolution co...
Next Document:  Development of a saliva collection device for use in the field.