| Association of adipose tissue blood flow with fat depot sizes and adipokines in women. | |
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MedLine Citation:
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PMID: 21792171 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective:To explore possible associations between adipose tissue (AT) blood flow (ATBF), AT depot sizes and adipocyte-derived hormones (adipokines) in women.Subjects:In all, 43 healthy women were divided into four groups: normal-weight (n=11) and obese (n=11) pre-menopausal women and normal-weight (n=10) and obese (n=11) post-menopausal women.Methods:Fasting levels of adipokines were obtained, and a single-slice computed tomography scan at the level of L4-L5 was used to estimate fat depot sizes. ATBF was assessed by xenon washout while in a fasting state and after oral glucose load. We also measured glucose, insulin and non-esterified fatty acids.Results:Total, subcutaneous and visceral AT areas strongly correlated with ATBF (all P<0.001). Circulating leptin levels strongly and inversely correlated with ATBF (P=0.001), but this association did not remain after adjustment for body mass index. Adiponectin was not associated with blood flow.Conclusion:ATBF is closely linked to subcutaneous and visceral AT size. Further analyses are needed to determine possible mediators of this association, including mechanistic studies to assess a putative role for leptin as a significant modulator of blood flow.International Journal of Obesity advance online publication, 26 July 2011; doi:10.1038/ijo.2011.152. |
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Authors:
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J Andersson; F Karpe; L-G Sjöström; K Riklund; S Söderberg; T Olsson |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-26 |
Journal Detail:
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Title: International journal of obesity (2005) Volume: - ISSN: 1476-5497 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256108 Medline TA: Int J Obes (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Department of Public Health and Clinical Medicine, Medicine, Umeå University, Umeå, Sweden [2] Heart Center, Umeå University Hospital, Umeå, Sweden. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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