Document Detail

Association of Vascular Endothelial Growth Factor +936 C/T Single-Nucleotide Polymorphism With Pregnancies Complicated by Small-for-Gestational-Age Babies.
MedLine Citation:
PMID:  22147779     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: To examine whether single-nucleotide polymorphisms (SNPs) in VEGFA (-2578 C/A and +936 C/T) associate with small-for-gestational-age (SGA) pregnancies and to identify their effects on first-trimester placental VEGFA expression.
DESIGN: Multicenter prospective cohort study. Settings  Adelaide, Australia, and Auckland, New Zealand.
PARTICIPANTS: A total of 3234 nulliparous pregnant women, their partners, and their infants.
MAIN OUTCOME MEASURES: The SNPs in the parent-infant trios and first-trimester placentae (n = 74) were genotyped. Placental VEGFA messenger RNA expression was determined by quantitative reverse transcription-polymerase chain reaction. Small for gestational age was defined as a birth weight less than the 10th customized birth weight percentile adjusted for maternal height, weight, parity, and ethnicity and for gestational age at delivery and infant sex. Uterine and umbilical artery Doppler was performed at 20 weeks' gestation, and resistance indices greater than the 90th percentile were considered abnormal.
RESULTS: Of 2123 pregnancies, 1176 (55.4%) were uncomplicated and 216 (10.2%) had SGA infants. Neonatal VEGFA +936 C/T SNP associates with SGA (adjusted odds ratio [aOR], 1.6; 95% CI, 1.0-2.3), SGA with abnormal Doppler findings (aOR, 3.5; 95% CI, 1.8-7.1), lower birth weight (P = .006), customized birth weight percentile (P = .049), and abnormal uterine artery Doppler findings (OR, 2.5; 95% CI, 1.2-5.4). Maternal VEGFA +936 C/T associates with abnormal umbilical artery Doppler findings (OR, 1.5; 95% CI, 1.1-2.2). VEGFA +936 CT+TT first-trimester placentae have 36% lower VEGFA messenger RNA expression compared with CC (P = .045).
CONCLUSION: Neonatal VEGFA +936 C/T associates with SGA, and the association is stronger for SGA with abnormal uterine or umbilical artery Doppler findings. The SNP also associates with reduced first-trimester placental VEGFA expression, suggesting that it may have a role in the pathogenesis of SGA. Trial Registration Identifier: ACTRN12607000551493.
Prabha H Andraweera; Gustaaf A Dekker; Steven D Thompson; Rachael C Nowak; Jamie V Zhang; Lesley M E McCowan; Robyn A North; Claire T Roberts
Related Documents :
21665449 - Pre-clinical validation of a vaginal cream containing copaiba oil (reproductive toxicol...
21763829 - Early delivery as an alternative management strategy for selected high-risk fetal sacro...
22019619 - Novel protocol for scheduling oocyte retrieval in ivm cycles in pcos patients: a case s...
21751829 - Delivery outcome after maternal use of drugs for migraine: a register study in sweden.
21824709 - Triggering final oocyte maturation with reduced doses of hcg in ivf/icsi: a prospective...
21714679 - Glycemic control and pregnancy outcomes in women with type 1 diabetes mellitus using li...
21815699 - Corifollitropin alfa: a review of its use in controlled ovarian stimulation for assiste...
8835969 - Role of endovaginal sonography in the diagnosis and management of ectopic pregnancy.
21665449 - Pre-clinical validation of a vaginal cream containing copaiba oil (reproductive toxicol...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  165     ISSN:  1538-3628     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1123-30     Citation Subset:  AIM; IM    
Obstetrics and Gynaecology, University of Adelaide Medical School North, North Adelaide, So 5005, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Helium-oxygen therapy for infants with bronchiolitis: a randomized controlled trial.
Next Document:  Valacyclovir suppressive therapy reduces plasma and breast milk HIV-1 RNA levels during pregnancy an...