| Association of vascular endothelial growth factor polymorphisms with nonproliferative and proliferative diabetic retinopathy. | |
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MedLine Citation:
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PMID: 20444917 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor, and its polymorphisms are associated with proliferative diabetic retinopathy (PDR) and macular edema. OBJECTIVE: We investigated the contributions of VEGF gene polymorphisms to nonproliferative diabetic retinopathy (NPDR) as well as PDR. DESIGN, SETTING, AND SUBJECTS: In this study we compared VEGF gene variants in a sample of Korean type 2 diabetes patients with and without diabetic retinopathy (DR) and in healthy controls. Of the diabetes patients, 145 had PDR, 108 had NPDR, and 134 had no retinopathy (noDR). They were all duration matched. Samples were genotyped for rs699947, rs1570360, and rs2010963 polymorphisms. RESULTS: We found a significant association between the A allele at rs699947 with DR (odds ratio = 1.84 (95% confidence interval = 1.28-2.66); P = 0.001 vs. noDR). Patients with NPDR, as well as PDR, had increased incidence of the A allele. The AGG haplotype was more frequently found in patients with DR than in patients with noDR (odds ratio = 4.79 (95% confidence interval = 1.42-16.16); P = 0.006). PDR and NPDR patients exhibited an increased incidence of the AGG haplotype. CONCLUSIONS: VEGF polymorphisms might be a useful predictive marker for the development and progression of DR at an earlier stage of diabetes. |
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Authors:
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Min-Young Chun; Hwan-Sik Hwang; Hee-Youn Cho; Ha-Jung Chun; Jung-Taek Woo; Kwan-Woo Lee; Mun-Suk Nam; Sei-Hyun Baik; Young-Seol Kim; Yongsoo Park |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-05 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 95 ISSN: 1945-7197 ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 3547-51 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine and Bioengineering, Hanyang University Hospital, Seoul 471-020, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alleles Asian Continental Ancestry Group / genetics Cell Proliferation Diabetic Retinopathy / genetics* Female Gene Frequency Genetic Association Studies Humans Male Odds Ratio Phenotype Polymorphism, Genetic / genetics* Vascular Endothelial Growth Factor A / genetics* |
| Chemical | |
Reg. No./Substance:
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0/Vascular Endothelial Growth Factor A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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