Document Detail


Association of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.
MedLine Citation:
PMID:  19956784     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A chromosome 9p21 locus is associated with coronary heart disease in 25 independent populations, but multiple clinically distinct phenotypes have been evaluated. Using angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single-nucleotide polymorphisms predict ischemic events (eg, myocardial infarction [MI]) among CAD patients.
METHODS AND RESULTS: Patients undergoing coronary angiography during 1994 to 2007 (population set 1A: n=1748; set 1B: n=1014) were evaluated for association of a 9p21 tagging single-nucleotide polymorphism (rs2383206, A 224 G) with incident MI and death events among patients with angiographically significant CAD. Another hypothesis evaluated rs2383206 in 2 additional angiographic sets of both CAD and non-CAD patients (set 2A: n=2122; set 2B: n=1466) for prevalent MI versus CAD/no MI (and for MI versus non-CAD and CAD/no MI versus non-CAD). No association of rs2383206 was found with events in set 1A (odds ratio, 0.95 per G allele; P trend=0.48) and set 1B (odds ratio, 0.91 per G allele; P trend=0.28) or with MI versus CAD/no MI in set 2A (odds ratio, 0.96 per G allele; P trend=0.57) and set 2B (odds ratio, 0.89 per G allele; P trend=0.21). In contrast, rs2383206 was associated with CAD/no MI compared with non-CAD (set 2A: P trend=0.0001; set 2B: P trend=0.0008).
CONCLUSIONS: The chromosome 9p21 locus was not associated with incident events or prevalent MI, although it did predict CAD diagnosis. This contradicts reports of a 9p21 association with MI, likely because of differences in phenotype assignment. This suggests that high-quality phenotyping for CAD and MI is required to dissect the specific contributions of genetic variation to each stage of coronary heart disease pathophysiology.
Authors:
Benjamin D Horne; John F Carlquist; Joseph B Muhlestein; Tami L Bair; Jeffrey L Anderson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Circulation. Cardiovascular genetics     Volume:  1     ISSN:  1942-3268     ISO Abbreviation:  Circ Cardiovasc Genet     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-12-31     Completed Date:  2010-03-02     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  101489144     Medline TA:  Circ Cardiovasc Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
Affiliation:
Cardiovascular Department, Intermountain Medical Center, Murray, UT 84157, USA. benjamin.horne@imail.org
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MeSH Terms
Descriptor/Qualifier:
Aged
Alleles
Case-Control Studies
Chromosomes, Human, Pair 9 / genetics*
Chronic Disease
Cohort Studies
Coronary Angiography
Coronary Artery Disease / genetics*
Female
Genetic Predisposition to Disease
Genotype
Humans
Longitudinal Studies
Middle Aged
Myocardial Infarction / genetics*
Phenotype
Polymorphism, Single Nucleotide
Risk Factors
Grant Support
ID/Acronym/Agency:
HL071878/HL/NHLBI NIH HHS; R01 HL071878-01A2/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
Circ Cardiovasc Genet. 2008 Dec;1(2):81-4   [PMID:  20031549 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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