Document Detail

Association of uric acid with change in kidney function in healthy normotensive individuals.
MedLine Citation:
PMID:  20385436     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Despite recent evidence, the role of uric acid as a causal factor in the pathogenesis and progression of kidney disease remains controversial, partly because of the inclusion in epidemiologic studies of patients with hypertension, diabetes, and/or proteinuria. STUDY DESIGN: Prospective observational cohort. SETTING & PARTICIPANTS: 900 healthy normotensive adult blood donors (153 women, 747 men) evaluated at baseline and after 5 years. PREDICTOR: Serum uric acid level. OUTCOMES: Decrease in estimated glomerular filtration rate (eGFR) >10 mL/min/1.73 m(2), computed using the Modification of Diet in Renal Disease (MDRD) Study equation, with secondary analyses examining similar decreases using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Cockcroft-Gault equations. RESULTS: During a median follow-up of 59 months, eGFR decreased from 97 +/- 16 to 88 +/- 14 mL/min/1.73 m(2). Higher serum uric acid levels were associated with a greater likelihood of eGFR decrease in both women and men (HR, 1.13 [95% CI, 1.04-1.39] per each 1-mg/dL increase in uric acid level); in multivariable analyses adjusting for age, sex, body mass index, blood glucose level, total cholesterol level, mean blood pressure, urine albumin-creatinine ratio, and serum triglyceride level, the association remained highly significant (HR, 1.28 [95% CI, 1.12-1.48]). Results were similar using different estimating equations and when the association was examined in sex-specific subgroups. LIMITATIONS: Analyses were based on a single baseline uric acid measurement. Women are underrepresented. CONCLUSIONS: In healthy normotensive individuals, serum uric acid level is an independent risk factor for decreased kidney function.
Gianni Bellomo; Sandro Venanzi; Claudio Verdura; Paolo Saronio; Antonella Esposito; Mario Timio
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Publication Detail:
Type:  Journal Article     Date:  2010-04-10
Journal Detail:
Title:  American journal of kidney diseases : the official journal of the National Kidney Foundation     Volume:  56     ISSN:  1523-6838     ISO Abbreviation:  Am. J. Kidney Dis.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-24     Revised Date:  2010-09-30    
Medline Journal Info:
Nlm Unique ID:  8110075     Medline TA:  Am J Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  264-72     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved.
Department of Nephrology, San Giovanni Battista Hospital, Foligno, Pg, Italy.
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MeSH Terms
Creatinine / blood
Glomerular Filtration Rate
Kidney / physiology*
Middle Aged
Proportional Hazards Models
Prospective Studies
Renal Insufficiency, Chronic / blood*,  physiopathology
Risk Factors
Uric Acid / blood*
Reg. No./Substance:
60-27-5/Creatinine; 69-93-2/Uric Acid
Comment In:
Am J Kidney Dis. 2010 Aug;56(2):247-50   [PMID:  20659624 ]
Nat Rev Nephrol. 2010 Oct;6(10):562

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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