| Association of thyroid autoantibodies with moyamoya-type cerebrovascular disease: a prospective study. | |
| | |
MedLine Citation:
|
PMID: 19926842 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND PURPOSE: To investigate the association between thyroid autoantibodies and moyamoya disease (MMD) in patients with an apparent euthyroid state. METHODS: We prospectively studied angiographically diagnosed patients with MMD. We compared demographic profiles, thyroid function test, and thyroid autoantibody status between MMD and control groups. RESULTS: A total of 63 patients with MMD, 71 patients with non-MMD stroke, and 200 healthy control subjects were included. The prevalence of elevated thyroid autoantibodies was higher in the MMD group than in other groups (P<0.01 for MMD versus non-MMD; P<0.001 for MMD versus control subjects). After adjusting for covariates, the elevated thyroid autoantibodies (OR, 4.871; 95% CI, 1.588 to 15.277) and smoking habits (OR, 0.206 for current smoker; 95% CI, 0.054 to 0.786) were independently associated with MMD versus non-MMD stroke. CONCLUSIONS: Elevated thyroid autoantibodies were frequently observed in patients with MMD. The results of the present study suggest that immune aberrancies associated with or underlying thyroid autoimmunity are also playing a role in developing MMD. |
| | |
Authors:
|
Suk Jae Kim; Kwang Gi Heo; Hee Young Shin; Oh Young Bang; Gyeong-Moon Kim; Chin-Sang Chung; Keon Ha Kim; Pyoung Jeon; Jong Soo Kim; Seung-Chyul Hong; Kwang Ho Lee |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-11-19 |
Journal Detail:
|
Title: Stroke; a journal of cerebral circulation Volume: 41 ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2009-12-29 Completed Date: 2010-01-28 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0235266 Medline TA: Stroke Country: United States |
Other Details:
|
Languages: eng Pagination: 173-6 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Samsung Medical Center, Sungkyunkwan University, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Autoantibodies / biosynthesis, blood* Child Cohort Studies Female Humans Male Middle Aged Moyamoya Disease / blood*, diagnosis Prospective Studies Thyroid Function Tests / methods Thyroid Hormones / blood* Young Adult |
| Chemical | |
Reg. No./Substance:
|
0/Autoantibodies; 0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Postthrombolysis Blood Pressure Elevation Is Associated With Hemorrhagic Transformation.
Next Document: Low Risk of Ipsilateral Stroke in Patients With Asymptomatic Carotid Stenosis on Best Medical Treatm...