Document Detail

Association of Tef polymorphism with depression in Parkinson disease.
MedLine Citation:
PMID:  23138696     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Circadian rhythm disturbance has been implicated in depression, and polymorphisms of circadian genes Cry1, Cry2, and Tef are associated with depression. However, the relationship between these genes and depression symptoms in Parkinson's disease (PD) has not been established.
METHODS: Four hundred eight subjects with PD participated in this study. Demographics, UPDRS, Mini-Mental Status Examination (MMSE), and Hamilton Rating Scale for Depression (HAMD) were obtained in all subjects. Frequency of polymorphisms of Cry1 rs2287161, Cry2 rs10838524, and Tef rs738499 was determined, and the association between genetic polymorphisms of circadian genes and HAMD scores in patients with PD was examined.
RESULTS: Tef, but not Cry1 or Cry2, is associated with HAMD scores in patients with PD in a linear regression model after adjusting for clinical variables (P = 0.004).
CONCLUSIONS: The polymorphism of Tef rs738499 is associated with depression symptoms in PD.
Ping Hua; Weiguo Liu; Sheng-Han Kuo; Yanyan Zhao; Ling Chen; Ning Zhang; Chun Wang; Suwan Guo; Li Wang; Hong Xiao; Justin Y Kwan; Tianxia Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-11-08
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  27     ISSN:  1531-8257     ISO Abbreviation:  Mov. Disord.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-05-13     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1694-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Movement Disorder Society.
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MeSH Terms
Basic-Leucine Zipper Transcription Factors / genetics*
Cryptochromes / genetics
Depression / etiology*,  genetics*
Gene Frequency
Genetic Association Studies
Mental Status Schedule
Middle Aged
Parkinson Disease / complications*
Polymorphism, Single Nucleotide / genetics*
Severity of Illness Index
Reg. No./Substance:
0/Basic-Leucine Zipper Transcription Factors; 0/CRY1 protein, human; 0/CRY2 protein, human; 0/Cryptochromes; 0/TEF protein, human

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