Document Detail

Association of target organ damage with three arterial stiffness indexes according to blood pressure dipping status in untreated hypertensive patients.
MedLine Citation:
PMID:  20671719     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Subclinical organ damage represents an intermediate stage in the continuum of vascular disease and a determinant of overall cardiovascular risk. We investigated the associations of pulse wave velocity (PWV), ambulatory arterial stiffness index (AASI), and office pulse pressure (PP) with several target organ damages (TODs) in newly diagnosed and never-treated patients with essential hypertension with respect to their dipping profile.
METHODS: One hundred sixty-eight hypertensive patients with recently diagnosed and never-treated stage I-II essential hypertension were evaluated with respect to the relationship of PWV, AASI, and office PP with TOD including microalbumin (MAU) levels, cognitive function, intima-media thickness (IMT), coronary flow reserve (CFR), left ventricular mass (LVM), left ventricular filling pressures, diastolic dysfunction, and left atrium (LA) enlargement.
RESULTS: Simultaneous estimation of AASI, PWV, and office PP independently associated with the following: (i) CFR (P < 0.01), 24-h urine albumin excretion rates (P < 0.05), left ventricular diastolic dysfunction (P < 0.01), and LA enlargement (P < 0.01) in never-treated hypertensive patients; (ii) CFR (P < 0.05), IMT (P < 0.01), left ventricular diastolic dysfunction (P < 0.05), and LA enlargement (P < 0.05) in dippers; and (iii) CFR (P < 0.05) and LA enlargement (P < 0.01) in nondippers. Nonindependent relationships revealed between (i) AASI and left ventricular filling pressures and (ii) PWV and cognitive dysfunction in never-treated hypertensive patients.
CONCLUSIONS: The simultaneous estimation of three noninvasive indexes of arterial stiffness leads to valuable information regarding their association with TOD including CFR, MAU levels, IMT, left ventricular diastolic dysfunction, and LA enlargement in never-treated hypertensive patients regarding their dipping status.
Helen Triantafyllidi; Stavros Tzortzis; John Lekakis; Ignatios Ikonomidis; Chrysa Arvaniti; Paraskevi Trivilou; Konstantinos Kontsas; Nikolaos Siafakas; Loukia Zerva; Eleftherios Stamboulis; Dimitrios Kremastinos; Maria Anastasiou-Nana
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Publication Detail:
Type:  Journal Article     Date:  2010-07-29
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-16     Completed Date:  2011-03-03     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1265-72     Citation Subset:  IM    
2nd Department of Cardiology, Attikon Hospital, Medical School, University of Athens, Athens, Greece.
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MeSH Terms
Arteries / physiopathology
Blood Flow Velocity
Blood Pressure*
Blood Pressure Monitoring, Ambulatory
Cardiovascular Diseases / etiology
Circadian Rhythm
Cross-Sectional Studies
Hypertension / physiopathology*
Middle Aged
Pulsatile Flow
Vascular Resistance*

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